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本文引用的文献

1
The yjbEFGH locus in Escherichia coli K-12 is an operon encoding proteins involved in exopolysaccharide production.大肠杆菌K-12中的yjbEFGH基因座是一个操纵子，编码参与胞外多糖产生的蛋白质。
Microbiology (Reading). 2007 Apr;153(Pt 4):1070-1080. doi: 10.1099/mic.0.2006/002907-0.
2
Acetyl phosphate-sensitive regulation of flagellar biogenesis and capsular biosynthesis depends on the Rcs phosphorelay.鞭毛生物合成和荚膜生物合成的乙酰磷酸敏感性调控依赖于Rcs磷酸化信号转导系统。
Mol Microbiol. 2006 Aug;61(3):734-47. doi: 10.1111/j.1365-2958.2006.05260.x. Epub 2006 Jun 15.
3
Regulation of bacterial virulence by two-component systems.双组分系统对细菌毒力的调控
Curr Opin Microbiol. 2006 Apr;9(2):143-52. doi: 10.1016/j.mib.2006.01.005. Epub 2006 Feb 14.
4
BapA, a large secreted protein required for biofilm formation and host colonization of Salmonella enterica serovar Enteritidis.BapA是肠炎沙门氏菌血清型肠炎杆菌形成生物膜和在宿主体内定殖所必需的一种大量分泌蛋白。
Mol Microbiol. 2005 Dec;58(5):1322-39. doi: 10.1111/j.1365-2958.2005.04907.x.
5
Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli.RcsF在大肠杆菌向Rcs磷酸化信号转导途径发出信号中的作用。
J Bacteriol. 2005 Oct;187(19):6770-8. doi: 10.1128/JB.187.19.6770-6778.2005.
6
The Rcs phosphorelay: a complex signal transduction system.Rcs磷酸化信号传递：一种复杂的信号转导系统。
Annu Rev Microbiol. 2005;59:379-405. doi: 10.1146/annurev.micro.59.050405.101230.
7
The PhoP/PhoQ system controls the intramacrophage type three secretion system of Salmonella enterica.PhoP/PhoQ系统控制肠炎沙门氏菌的巨噬细胞内Ⅲ型分泌系统。
Mol Microbiol. 2005 Jul;57(1):85-96. doi: 10.1111/j.1365-2958.2005.04668.x.
8
Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system.具有Rcs系统组成性激活的肠炎沙门氏菌rcsC突变体中的毒力减弱
Microbiology (Reading). 2005 Feb;151(Pt 2):579-588. doi: 10.1099/mic.0.27520-0.
9
Identification of host-specific colonization factors of Salmonella enterica serovar Typhimurium.肠炎沙门氏菌鼠伤寒血清型宿主特异性定植因子的鉴定
Mol Microbiol. 2004 Nov;54(4):994-1010. doi: 10.1111/j.1365-2958.2004.04323.x.
10
The Salmonella membrane protein IgaA modulates the activity of the RcsC-YojN-RcsB and PhoP-PhoQ regulons.鼠伤寒沙门氏菌膜蛋白IgaA可调节RcsC-YojN-RcsB和PhoP-PhoQ调节子的活性。
J Bacteriol. 2004 Nov;186(22):7481-9. doi: 10.1128/JB.186.22.7481-7489.2004.

Rcs和PhoPQ在调控肠炎沙门氏菌毒力方面存在调控重叠。

Rcs and PhoPQ regulatory overlap in the control of Salmonella enterica virulence.

作者信息

García-Calderón Clara B, Casadesús Josep, Ramos-Morales Francisco

机构信息

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Avda Reina Mercedes, 6, 41012 Sevilla, Spain.

出版信息

J Bacteriol. 2007 Sep;189(18):6635-44. doi: 10.1128/JB.00640-07. Epub 2007 Jul 6.

DOI:10.1128/JB.00640-07
PMID:17616593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2045174/
Abstract

Genetic screens based on the use of MudJ-generated lac fusions permitted the identification of novel genes regulated by the Rcs signal transduction system in Salmonella enterica serovar Typhimurium. Besides genes that are also found in the Escherichia coli genome, our screens identified Salmonella-specific genes regulated by RcsB, including bapA, siiE, srfA, and srfB. Here we show that the srfABC operon is negatively regulated by RcsB and by PhoP. In vivo studies using mutants with constitutive activation of the Rcs and/or PhoPQ system suggested that there is an overlap between these regulatory systems in the control of Salmonella virulence.

摘要

基于使用 MudJ 产生的 lac 融合体的遗传筛选，使得在鼠伤寒沙门氏菌中能够鉴定出受 Rcs 信号转导系统调控的新基因。除了在大肠杆菌基因组中也存在的基因外，我们的筛选还鉴定出了受 RcsB 调控的沙门氏菌特异性基因，包括 bapA、siiE、srfA 和 srfB。在这里我们表明，srfABC 操纵子受到 RcsB 和 PhoP 的负调控。使用 Rcs 和/或 PhoPQ 系统组成型激活的突变体进行的体内研究表明，在沙门氏菌毒力控制方面，这些调控系统之间存在重叠。