Torry Donald S, Leavenworth Jonathan, Chang Miao, Maheshwari Vatsala, Groesch Kathleen, Ball Evan R, Torry Ronald J
Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, P.O. Box 19626, Springfield, IL 62794-9626, USA.
J Assist Reprod Genet. 2007 Jul;24(7):303-15. doi: 10.1007/s10815-007-9152-7.
Implantation failure and early pregnancy loss are common following natural conceptions and they are particularly important clinical hurdles to overcome following assisted reproduction attempts. The importance of adequate vascular development and maintenance during implantation has recently become a major focus of investigation.
Review of current published literature was undertaken to summerize the cells and cell products that regulate tissue vascularity during implantation.
Vascular development at the maternal fetal interface can be regulated by a number of different cell types; two principal candidates are trophoblast and natural killer cells. A wide range of soluble factors, some with well established angiogenic functions as well as other more novel factors, can contribute to vascular development and maintenance at the maternal-fetal interface.
Robust vascular development occurs during implantation and early placentation of normal pregnancies. Studies to define the extent and mechanisms by which defects in vascularity contribute to human implantation failure and early miscarriage need to be undertaken.
自然受孕后着床失败和早期妊娠丢失很常见，而在辅助生殖尝试后，它们更是需要克服的重要临床障碍。着床期间充分的血管发育和维持的重要性最近已成为研究的主要焦点。
对当前已发表的文献进行综述，以总结着床期间调节组织血管形成的细胞和细胞产物。
母胎界面处的血管发育可由多种不同细胞类型调节；两个主要候选细胞是滋养层细胞和自然杀伤细胞。多种可溶性因子，一些具有已明确的血管生成功能以及其他更新颖的因子，可有助于母胎界面处的血管发育和维持。
正常妊娠的着床和早期胎盘形成过程中会发生强劲的血管发育。需要开展研究来确定血管缺陷导致人类着床失败和早期流产的程度及机制。
