Goodger A M, Rogers P A
Department of Obstetrics and Gynaecology, Monash University, Clayton, Australia.
Microcirculation. 1995 Dec;2(4):329-43. doi: 10.3109/10739689509148277.
Angiogenesis, or formation of new blood vessels by sprout formation from existing vessels, is generally considered to be the only mechanism by which blood vessel growth occurs. This traditional concept of angiogenesis has been derived largely from observations of experimental systems. Relatively fewer studies on angiogenesis have been carried out using normal angiogenic situations where vessel growth occurs in a controlled three-dimensional fashion throughout the tissue. Recent advances in the treatment of infertility and outpatient gynecological procedures have led to greater accessibility to normal human endometrium, thus providing new opportunities to study the process of angiogenesis in a physiological context. However, to date, it appears that very little work had been done in relation to endometrial angiogenesis apart from the location of numerous angiogenic and other growth factors with potential to influence angiogenesis in the endometrium, and here there have been few attempts to link these observations with actual angiogenic events. The purpose of this review is to summarize the literature regarding angiogenesis in the endometrium, including work from our own laboratory, and to suggest that blood vessel growth in the endometrium may occur by a mechanism that differs from classical angiogenesis.
血管生成，即通过从现有血管发芽形成新血管，通常被认为是血管生长发生的唯一机制。这种传统的血管生成概念主要源于对实验系统的观察。相对较少使用正常血管生成情况进行血管生成研究，在正常血管生成情况下，血管生长以可控的三维方式在整个组织中发生。不孕症治疗和门诊妇科手术的最新进展使人们更容易获取正常的人类子宫内膜，从而为在生理背景下研究血管生成过程提供了新机会。然而，迄今为止，除了在子宫内膜中定位众多具有影响血管生成潜力的血管生成因子和其他生长因子外，似乎很少有关于子宫内膜血管生成的研究，而且很少有人尝试将这些观察结果与实际的血管生成事件联系起来。本综述的目的是总结有关子宫内膜血管生成的文献，包括我们自己实验室的研究工作，并提出子宫内膜中的血管生长可能通过一种不同于经典血管生成的机制发生。
