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Mycobacterium paratuberculosis antigen D: characterization and evidence that it is a bacterioferritin.

作者信息

Brooks B W, Young N M, Watson D C, Robertson R H, Sugden E A, Nielsen K H, Becker S A

机构信息

Agriculture Canada, Animal Diseases Research Institute, Nepean, Ontario, Canada.

出版信息

J Clin Microbiol. 1991 Aug;29(8):1652-8. doi: 10.1128/jcm.29.8.1652-1658.1991.

DOI:10.1128/jcm.29.8.1652-1658.1991
PMID:1761687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC270179/
Abstract

By using a combination of agarose and polyacrylamide gel electrophoresis, Mycobacterium paratuberculosis antigen D was resolved from a crude sonicated preparation of the organism and characterized as a component with a molecular mass of approximately 400,000 Da. While this component was composed mainly of protein, with unusually high proportions of glutamic acid and leucine, it was resistant to digestion with a number of proteolytic enzymes. Structural detail revealed by electron microscopy, amino acid sequence data, and the demonstration of a Soret band in its absorption spectrum indicated that antigen D was similar to an Escherichia coli bacterioferritin.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/0b6780e88d75/jcm00044-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/84e0a04d9490/jcm00044-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/f721710fc48b/jcm00044-0120-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/ef4f3d36e108/jcm00044-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/0b6780e88d75/jcm00044-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/84e0a04d9490/jcm00044-0120-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/f721710fc48b/jcm00044-0120-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/ef4f3d36e108/jcm00044-0121-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/10d8/270179/0b6780e88d75/jcm00044-0122-a.jpg

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本文引用的文献

1
The composition and the structure of bacterioferritin of Escherichia coli.大肠杆菌细菌铁蛋白的组成与结构。
Biochem J. 1981 Jul 1;197(1):171-5. doi: 10.1042/bj1970171.
2
The identity of bacterioferritin and cytochrome b1.细菌铁蛋白与细胞色素b1的同一性
Biochem J. 1983 May 1;211(2):527. doi: 10.1042/bj2110527.
3
Ruminant paratuberculosis (Johne's disease): the current status and future prospects.反刍动物副结核病（约内氏病）：现状与未来展望
分枝杆菌的组蛋白样蛋白具有铁蛋白超家族蛋白样活性，并能通过芬顿反应防止 DNA 损伤。
PLoS One. 2011;6(6):e20985. doi: 10.1371/journal.pone.0020985. Epub 2011 Jun 16.
4
An antifungal protein from the marine bacterium streptomyces sp. Strain AP77 is specific for Pythium porphyrae, a causative agent of red rot disease in Porphyra spp.一种来自海洋细菌链霉菌属菌株AP77的抗真菌蛋白对紫菜丝囊菌具有特异性，紫菜丝囊菌是紫菜属中红腐病的病原体。
Appl Environ Microbiol. 2002 Jun;68(6):2666-75. doi: 10.1128/AEM.68.6.2666-2675.2002.
5
Alkyl hydroperoxide reductases C and D are major antigens constitutively expressed by Mycobacterium avium subsp. paratuberculosis.烷基过氧化氢还原酶C和D是副结核分枝杆菌亚种组成性表达的主要抗原。
Infect Immun. 2000 Feb;68(2):801-8. doi: 10.1128/IAI.68.2.801-808.2000.
6
Response to reactive nitrogen intermediates in Mycobacterium tuberculosis: induction of the 16-kilodalton alpha-crystallin homolog by exposure to nitric oxide donors.结核分枝杆菌对活性氮中间体的反应：通过暴露于一氧化氮供体诱导16千道尔顿α-晶状体蛋白同源物的产生。
Infect Immun. 1999 Jan;67(1):460-5. doi: 10.1128/IAI.67.1.460-465.1999.
7
Survival of a bacterioferritin deletion mutant of Brucella melitensis 16M in human monocyte-derived macrophages.布鲁氏菌16M细菌铁蛋白缺失突变体在人单核细胞衍生巨噬细胞中的存活情况。
Infect Immun. 1997 Oct;65(10):4337-40. doi: 10.1128/iai.65.10.4337-4340.1997.
8
Analysis of culture filtrate and cell wall-associated antigens of Mycobacterium paratuberculosis with monoclonal antibodies.用单克隆抗体分析副结核分枝杆菌的培养滤液和细胞壁相关抗原。
Infect Immun. 1997 Feb;65(2):387-94. doi: 10.1128/iai.65.2.387-394.1997.
9
Purification, characterization, gene sequence, and significance of a bacterioferritin from Mycobacterium leprae.麻风分枝杆菌细菌铁蛋白的纯化、特性、基因序列及意义
J Exp Med. 1994 Jul 1;180(1):319-27. doi: 10.1084/jem.180.1.319.
10
Structural heterogeneity of Pseudomonas aeruginosa bacterioferritin.铜绿假单胞菌细菌铁蛋白的结构异质性
Biochem J. 1994 Dec 1;304 ( Pt 2)(Pt 2):493-7. doi: 10.1042/bj3040493.
Cornell Vet. 1984 Jul;74(3):218-62.
4
Diagnosis and control of bovine paratuberculosis (Johne's disease).牛副结核病（约内氏病）的诊断与防控
Adv Vet Sci Comp Med. 1983;27:481-506.
5
A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.一种用于检测聚丙烯酰胺凝胶中脂多糖的灵敏银染法。
Anal Biochem. 1982 Jan 1;119(1):115-9. doi: 10.1016/0003-2697(82)90673-x.
6
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
7
Chemical and immunological studies on polysaccharide antigens of mycobacteria, nocardia and corynebacteria.分枝杆菌、诺卡菌和棒状杆菌多糖抗原的化学与免疫学研究
Bull Int Union Tuberc. 1972 Feb;47:181-91.
8
Tandem-crossed immunoelectrophoresis.串联交叉免疫电泳
Scand J Immunol Suppl. 1973;1:57-9.
9
A hemoprotein from azotobacter containing non-heme iron: isolation and crystallization.一种来自固氮菌的含非血红素铁的血红素蛋白：分离与结晶
Biochem Biophys Res Commun. 1973 Oct 15;54(4):1274-81. doi: 10.1016/0006-291x(73)91125-x.
10
Antimycobacterial antibodies in sera from patients throughout the clinico-pathological disease spectrum of leprosy.
Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Oct;82B(5):701-6. doi: 10.1111/j.1699-0463.1974.tb00238.x.