Riemann H P, Abbas B
Adv Vet Sci Comp Med. 1983;27:481-506.
The literature on Johne's disease is quite extensive. The disease has been diagnosed throughout the world in a wide range of domestic and wild animals, but mainly ruminants. It is of economic importance only in cattle, sheep, and goats. A diagnostic test that is both sensitive and specific has not yet been found. This failure may be due either to the spectral nature of the immune response in an affected animal or to the impurities of the antigen preparations utilized in the various tests. Control and eradication of the disease is still in the research stage. Vaccination has been adopted mainly in Europe, with apparently satisfactory results. Vaccine evaluation has not always been correctly carried out. Several other control strategies have been attempted or suggested. None has been finally evaluated, and the disease is still a challenging problem.
关于副结核的文献颇为丰富。这种疾病在世界各地的多种家畜和野生动物中都有诊断记录，但主要发生在反刍动物身上。它仅在牛、绵羊和山羊身上具有经济重要性。尚未找到一种既敏感又特异的诊断测试。这种失败可能是由于患病动物免疫反应的光谱性质，或者是由于各种测试中使用的抗原制剂不纯。该疾病的控制和根除仍处于研究阶段。疫苗接种主要在欧洲采用，效果显然令人满意。疫苗评估并非总是正确进行。已经尝试或提出了其他几种控制策略。但都尚未得到最终评估，该疾病仍然是一个具有挑战性的问题。
