Leland D S, Zimmerman S E, Cunningham E B, Barth K A, Smith J W
Indiana University Medical Center, Indianapolis 46202-5200.
J Clin Microbiol. 1991 Aug;29(8):1723-4. doi: 10.1128/jcm.29.8.1723-1724.1991.
Using Immuno-Mycologics (IMMY; Norman, Okla.) histoplasmal yeast (HY) and mycelial (HM) antibody complement fixation test antigens, we retested 1,386 samples that were initially tested with Meridian Diagnostics, Inc. (Cincinnati, Ohio), antigens. Histoplasma antibody was identified (greater than or equal to 1:16) in 20% of HY and 5% of HM samples reported to have titers of less than 1:8 with Meridian reagents. IMMY titers were at least fourfold higher than Meridian titers in 39% of HY and 54% of HM samples that initially had titers of greater than or equal to 1:8 with Meridian antigens. Because 30 of 58 (52%) samples from confirmed cases of histoplasmosis yielded negative results with Meridian antigens and positive results upon retesting with IMMY antigens, we concluded that the Meridian antigens had less reactivity with human histoplasmal antibody.
使用免疫真菌学公司（IMMY；俄克拉荷马州诺曼市）的组织胞浆菌酵母（HY）和菌丝体（HM）抗体补体结合试验抗原，我们对最初使用子午线诊断公司（俄亥俄州辛辛那提市）抗原检测的1386份样本进行了重新检测。在报告使用子午线试剂时滴度低于1:8的样本中，20%的HY样本和5%的HM样本中检测到组织胞浆菌抗体（大于或等于1:16）。在最初使用子午线抗原时滴度大于或等于1:8的样本中，39%的HY样本和54%的HM样本中，IMMY滴度至少比子午线滴度高四倍。由于58例组织胞浆菌病确诊病例中的30份样本（52%）使用子午线抗原检测结果为阴性，而使用IMMY抗原重新检测结果为阳性，我们得出结论，子午线抗原与人组织胞浆菌抗体的反应性较低。
