C反应蛋白是宫颈癌患者的一个预后参数。
C-reactive protein is a prognostic parameter in patients with cervical cancer.
作者信息
Polterauer Stephan, Grimm Christoph, Tempfer Clemens, Sliutz Gerhard, Speiser Paul, Reinthaller Alexander, Hefler Lukas A
机构信息
Department of Obstetrics and Gynecology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.
出版信息
Gynecol Oncol. 2007 Oct;107(1):114-7. doi: 10.1016/j.ygyno.2007.06.001. Epub 2007 Jul 6.
OBJECTIVE
To evaluate whether C-reactive protein (CRP) serum levels can be used as a prognostic parameter in patients with cervical cancer.
METHODS
In the present study, CRP serum levels were measured in 215 patients with cervical cancer. CRP serum levels were measured prior to therapy for cervical cancer and were correlated to clinical data.
RESULTS
The median CRP serum level in patients with cervical cancer was 0.5 mg/dl (interquartile range 0.5-0.9 mg/dl). CRP serum levels were significantly associated with advanced tumor stage (p<0.001), lymph node involvement (p=0.01) and patients' age (p=0.01), but not with histological grade (p=0.1) and histological type (p=0.9). In a univariate and multivariate analysis CRP serum levels, tumor stage, and lymph node involvement, but not histological grade, histological type and patients' age were associated with overall and disease-free survival.
CONCLUSION
CRP serum levels can be used as additional prognostic parameter in patients with cervical cancer.
目的
评估血清C反应蛋白（CRP）水平是否可作为宫颈癌患者的预后参数。
方法
在本研究中，对215例宫颈癌患者测定了血清CRP水平。在宫颈癌治疗前测定血清CRP水平，并将其与临床数据相关联。
结果
宫颈癌患者血清CRP水平中位数为0.5mg/dl（四分位间距0.5 - 0.9mg/dl）。血清CRP水平与肿瘤晚期（p<0.001）、淋巴结受累（p = 0.01）及患者年龄（p = 0.01）显著相关，但与组织学分级（p = 0.1）和组织学类型（p = 0.9）无关。在单因素和多因素分析中，血清CRP水平、肿瘤分期和淋巴结受累与总生存期和无病生存期相关，但组织学分级、组织学类型和患者年龄与之无关。
结论
血清CRP水平可作为宫颈癌患者的额外预后参数。
Zotero 插件