Oka Tsunehiro, Sato Fumihiko, Ono Takeharu, Kawaguchi Toshihiko, Murotani Kenta, Sueyoshi Shintaro, Kuroiwa Taikai, Kurita Takashi, Fukahori Mioko, Mitsuhashi Toshiyuki, Sato Kiminobu, Chitose Shun-Ichi, Umeno Hirohito
Department of Otolaryngology-Head and Neck Surgery Kurume University School of Medicine Kurume Japan.
Biostatistics Center Kurume University Kurume Japan.
Laryngoscope Investig Otolaryngol. 2023 May 3;8(3):675-685. doi: 10.1002/lio2.1070. eCollection 2023 Jun.
Pretreatment systemic inflammation and nutrition-based prognostic indices (SINBPI) have demonstrated significance. This study investigated the prognostic value of pretreatment SINBPI for patients with oropharyngeal cancer and identified unfavorable prognostic markers.
We retrospectively reviewed the data of 124 patients with oropharyngeal squamous cell carcinoma (OPSCC) who received definitive treatment between January 2010 and December 2018. The prognostic utility of the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), prognostic nutritional index, and high-sensitivity modified Glasgow prognostic score (HS-mGPS) was assessed for disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS) using univariate and multivariate analyses.
Multivariate analyses revealed that human papillomavirus (HPV) status and HS-mGPS were significantly associated with DFS, DSS, and OS. Patients with a HS-mGPS of 2 had a significantly higher rate of treatment-related deaths than those with a HS-mGPS of 0 or 1. The combination of the HS-mGPS and PLR had more accurate predictive ability in DFS and OS compared with the HS-mGPS alone, and the combination of the HS-mGPS and LMR had more accurate predictive ability in DSS and OS.
Our results indicated that the HS-mGPS was a useful prognostic marker for patients with OPSCC, and combined markers consisting of the HS-mGPS and PLR or LMR may provide more accurate prognostic predictions.Level of Evidence: 3.
治疗前全身炎症和基于营养的预后指标（SINBPI）已显示出其重要性。本研究调查了治疗前SINBPI对口咽癌患者的预后价值，并确定了不良预后标志物。
我们回顾性分析了2010年1月至2018年12月期间接受根治性治疗的124例口咽鳞状细胞癌（OPSCC）患者的数据。通过单因素和多因素分析评估中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）、预后营养指数和高敏改良格拉斯哥预后评分（HS-mGPS）对无病生存期（DFS）、疾病特异性生存期（DSS）和总生存期（OS）的预后价值。
多因素分析显示，人乳头瘤病毒（HPV）状态和HS-mGPS与DFS、DSS和OS显著相关。HS-mGPS为2的患者治疗相关死亡率显著高于HS-mGPS为0或1的患者。与单独使用HS-mGPS相比，HS-mGPS与PLR的组合在DFS和OS方面具有更准确的预测能力，HS-mGPS与LMR的组合在DSS和OS方面具有更准确预测能力。
我们的结果表明，HS-mGPS是OPSCC患者有用的预后标志物，由HS-mGPS与PLR或LMR组成的联合标志物可能提供更准确的预后预测。证据级别：3级。
