来自海洋疣孢菌属菌株AB-18-032的阿比斯霉素G、H和阿托-阿比斯霉素C。
Abyssomicins G and H and atrop-abyssomicin C from the marine Verrucosispora strain AB-18-032.
作者信息
Keller Simone, Nicholson Graeme, Drahl Carmen, Sorensen Erik, Fiedler Hans-Peter, Süssmuth Roderich D
机构信息
Institut für Chemie, FG Organische Chemie, Technische Universität Berlin, Germany.
出版信息
J Antibiot (Tokyo). 2007 Jun;60(6):391-4. doi: 10.1038/ja.2007.54.
Abyssomicin C is a complex polyketide-type antibiotic and the first natural inhibitor of the p-aminobenzoate biosynthesis produced by the marine Verrucosispora strain AB-18-032. We have now isolated three novel naturally produced abyssomicins, among them the even more active atrop-abyssomicin C. The chemical structures were elucidated by mass spectrometry and NMR spectroscopy.
深海霉素C是一种复杂的聚酮类抗生素，是海洋疣孢菌属菌株AB - 18 - 032产生的对氨基苯甲酸生物合成的首个天然抑制剂。我们现已分离出三种新的天然产生的深海霉素，其中活性更强的是阿托-深海霉素C。通过质谱和核磁共振光谱对其化学结构进行了阐明。
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