AbsH3 的晶体结构：深渊霉素生物合成途径中一种假定的黄素腺嘌呤二核苷酸依赖性还原酶。
The crystal structure of AbsH3: A putative flavin adenine dinucleotide-dependent reductase in the abyssomicin biosynthesis pathway.
机构信息
Department of Biosciences, Rice University, Houston, Texas, USA.
Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
出版信息
Proteins. 2021 Jan;89(1):132-137. doi: 10.1002/prot.25994. Epub 2020 Oct 21.
Abstract
Natural products and natural product-derived compounds have been widely used for pharmaceuticals for many years, and the search for new natural products that may have interesting activity is ongoing. Abyssomicins are natural product molecules that have antibiotic activity via inhibition of the folate synthesis pathway in microbiota. These compounds also appear to undergo a required [4 + 2] cycloaddition in their biosynthetic pathway. Here we report the structure of an flavin adenine dinucleotide-dependent reductase, AbsH3, from the biosynthetic gene cluster of novel abyssomicins found in Streptomyces sp. LC-6-2.
摘要
天然产物及其衍生化合物多年来一直被广泛应用于药物研发，目前仍在不断探索可能具有有趣活性的新天然产物。深渊霉素是一种天然产物分子，通过抑制微生物群的叶酸合成途径具有抗生素活性。这些化合物在其生物合成途径中似乎也经历了一个必需的[4+2]环加成反应。在这里，我们报告了来自链霉菌 sp. LC-6-2 中发现的新型深渊霉素生物合成基因簇中的黄素腺嘌呤二核苷酸依赖性还原酶 AbsH3 的结构。
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