Philipsen Hans Peter, Reichart Peter A, Siar Chong Huat, Ng Kok Han, Lau Shin Hin, Zhang Xiaolin, Dhanuthai Kittipong, Swasdison Somporn, Jainkittivong Aree, Meer Shabnum, Jivan Vibha, Altini Mario, Hazarey Vinay, Ogawa Ikuko, Takata Takashi, Taylor Adalberto Abel Mosqueda, Godoy Héctor, Delgado Wilson A, Carlos-Bregni Roman, Macias Juan Fransisco Reyes, Matsuzaka Kenichi, Sato Daisuke, Vargas Pablo A, Adebayo Ezekiel Taiwo
Edificio El Condór 30, Urb. Guadalmina Alta, San Pedro de Alcántara, Spain.
J Oral Pathol Med. 2007 Aug;36(7):383-93. doi: 10.1111/j.1600-0714.2007.00536.x.
Adenomatoid odontogenic tumour (AOT) is a benign odontogenic jaw lesion. The aim of this study was to update the biological profile of AOT.
Cases published in the literature and cases in files of co-authors were included.
550 new cases were retrieved, and of a total of 1082 cases analysed, 87.2% were found in the second and third decades. The M:F ratio was 1:1.9. 70.8% were of the follicular variant (extrafollicular: 26.9%, peripheral: 2.3%). 64.3% occurred in the maxilla. 60% of follicular AOTs were associated with unerupted canines. Nineteen cases of AOT (2.8%, M:F ratio was 1:1.4) were associated with embedded third molars. Twenty-two peripheral AOTs (2.3%, M:F ratio was 1:5.3) were recorded. The relative frequency (RF) of AOT ranged between 0.6% and 38.5%, revealing a considerably wider AOT/RF range than hitherto reported (2.2-7.1%).
This updated review based on the largest number of AOT cases ever presented, confirms the distinctive, although not pathognomonic clinicopathological profile of the AOT, its worldwide occurrence, and its consistently benign behaviour.
腺样牙源性肿瘤（AOT）是一种良性牙源性颌骨病变。本研究的目的是更新腺样牙源性肿瘤的生物学特征。
纳入文献报道的病例以及共同作者档案中的病例。
检索到550例新病例，在总共分析的1082例病例中，87.2%发生在第二个和第三个十年。男女比例为1:1.9。70.8%为滤泡型（滤泡外型：26.9%，周边型：2.3%）。64.3%发生在上颌骨。60%的滤泡型AOT与未萌出的尖牙有关。19例AOT（2.8%，男女比例为1:1.4）与埋伏阻生的第三磨牙有关。记录到22例周边型AOT（2.3%，男女比例为1:5.3）。AOT的相对发病率（RF）在0.6%至38.5%之间，显示出比迄今报道的（2.2 - 7.1%）更宽的AOT/RF范围。
基于有史以来最大数量的AOT病例进行的本次更新综述，证实了AOT独特的临床病理特征（尽管并非特异性）、其在全球的发病情况以及始终良性的行为。
