School of Dental Medicine, University of Pittsburgh, G-135 Salk Hall, 3501 Terrace Street, Pittsburgh, PA, 15261, USA.
Academic Unit of Oral and Maxillofacial Medicine and Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Head Neck Pathol. 2021 Mar;15(1):71-84. doi: 10.1007/s12105-020-01284-3. Epub 2021 Mar 15.
This article reviews odontogenic and developmental oral lesions encountered in the gnathic region of pediatric patients. The process of odontogenesis is discussed as it is essential to understanding the pathogenesis of odontogenic tumors. The clinical presentation, microscopic features, and prognosis are addressed for odontogenic lesions in the neonate (dental lamina cysts/gingival cysts of the newborn, congenital (granular cell) epulis of the newborn, melanotic neuroectodermal tumor, choristoma/heterotopia, cysts of foregut origin), lesions associated with unerupted/erupting teeth (hyperplastic dental follicle, eruption cyst, dentigerous cyst, odontogenic keratocyst/keratocystic odonogenic tumor, buccal bifurcation cyst/inflammatory collateral cyst) and pediatric odontogenic hamartomas and tumors (odontoma, ameloblastic fibroma, ameloblastoma, adenomatoid odontogenic tumor, primordial odontogenic tumor). Pediatric odontogenic and developmental oral lesions range from common to rare, but familiarity with these entities is essential due to the varying management implications of these diagnoses.
本文回顾了儿童颌面部的牙源性和发育性口腔病变。讨论了牙发生过程，因为这对于理解牙源性肿瘤的发病机制至关重要。介绍了新生儿期的牙源性病变（牙板囊肿/新生儿牙龈囊肿、先天性（颗粒细胞）新生儿龈瘤、黑色素神经外胚层肿瘤、错构瘤/异位、前肠来源的囊肿）、未萌出/萌出牙齿相关病变（增生性牙滤泡、萌出囊肿、含牙囊肿、牙源性角化囊肿/角化囊性牙源性肿瘤、颊侧分又囊肿/炎症性副管囊肿）和儿童牙源性错构瘤和肿瘤（牙瘤、成釉细胞瘤纤维瘤、成釉细胞瘤、牙源性腺样瘤、原始性牙源性肿瘤）的临床表现、组织学特征和预后。儿科牙源性和发育性口腔病变既有常见的也有罕见的，但由于这些诊断的治疗意义不同，熟悉这些病变是很有必要的。
