Ramachandra Prashanth, Bavle Radhika M, Muniswamappa Sudhakara, Venugopal Reshma
Department of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.
J Oral Maxillofac Pathol. 2022 Oct-Dec;26(4):564-567. doi: 10.4103/jomfp.jomfp_166_22. Epub 2022 Dec 22.
The Adenomatoid Odontogenic Tumour (AOT) is more than 100 years old, known by different names and the term AOT was coined in 1969 by Philipsen and Birn. AOT frequently occurs in intra-osseous location in gnathic skeleton and rarely seen in peripheral forms. These are rare odontogenic tumours, accounting for 2.2--7.1% of all odontogenic tumours, whereas the central or intraosseous variant of AOT in follicular and extra-follicular presentation, accounts for 95.6% of all AOTs. The peripheral variant presents as a gingival mass, which may cause slight saucerization of alveolar bone or might not affect the bone at all. These peripheral variants constitute 4.4% or less, of all AOTs of the gnathic skeleton. Here, we present a rare case of a peripheral variant of AOT in a 35-years-old female, 1.5 to 2 cm in dimension seen on the labial gingiva in right canine-premolar area. The lesion showed marked bone loss in 13 and 14 teeth region, causing mobility of 13. Histopathology showed a well encapsulated tumour mass with metaplastic bone in the capsule. A conventional AOT with ductal and rosette pattern was seen with tumour droplets and amyloid like material. The case clinically presented a moderately aggressive behaviour.
腺样牙源性肿瘤（AOT）已有100多年的历史，曾有不同的名称，“AOT”这一术语由菲利普森（Philipsen）和比尔恩（Birn）于1969年提出。AOT常发生于颌骨骨骼的骨内位置，外周型罕见。这些是罕见的牙源性肿瘤，占所有牙源性肿瘤的2.2% - 7.1%，而滤泡型和滤泡外型的中央型或骨内型AOT占所有AOT的95.6%。外周型表现为牙龈肿物，可能导致牙槽骨轻度碟形凹陷，也可能根本不影响骨质。这些外周型占颌骨骨骼所有AOT的4.4%或更少。在此，我们报告一例罕见的35岁女性外周型AOT病例，肿物大小为1.5至2厘米，位于右侧尖牙-前磨牙区的唇侧牙龈。病变在13和14牙区显示明显骨质吸收，导致13牙松动。组织病理学显示肿瘤块包膜完整，包膜内有化生骨。可见具有导管和玫瑰花结样结构的典型AOT，伴有肿瘤小滴和淀粉样物质。该病例临床呈现中度侵袭性行为。
