Pallas D, Koutras D A, Adamopoulos P, Marafelia P, Souvatzoglou A, Piperingos G, Moulopoulos S D
Athens University, Department of Clinical Therapeutics, Alexandra General Hospital, Greece.
J Endocrinol Invest. 1991 Oct;14(9):743-6. doi: 10.1007/BF03347907.
Serum thyroid hormones and antithyroid autoantibodies (AAB) were assayed in 87 randomly selected hypercholesterolemic persons compared to 80 controls with normal serum total cholesterol (TC). Of the 87 hypercholesterolemic persons 22 (25%) had positive AAB compared to 5 (6%) controls. Furthermore, 8 of the hypercholesterolemic patients had a serum TSH level above 5 mU/l, i.e. the had subclinical hypothyroidism, not diagnosed before, whereas thyroid function was normal in all normocholesterolemic persons. The new and unexpected finding was that the hypercholesterolemic persons had on average a significantly higher serum TSH than the controls, and this was true even when persons with positive AAB were excluded. There was a significant correlation between TC and serum TSH. It is concluded that hypothyroidism may not be an all-or-none phenomenon, and that many hypercholesterolemic persons with thyroid tests within the conventional normal range may have a slight impairment of their thyroid function.
对87名随机选取的高胆固醇血症患者测定了血清甲状腺激素和抗甲状腺自身抗体（AAB），并与80名血清总胆固醇（TC）正常的对照者进行比较。87名高胆固醇血症患者中，22人（25%）AAB呈阳性，而对照者中有5人（6%）呈阳性。此外，8名高胆固醇血症患者的血清促甲状腺激素（TSH）水平高于5 mU/l，即他们患有此前未被诊断出的亚临床甲状腺功能减退，而所有胆固醇正常者的甲状腺功能均正常。新的意外发现是，高胆固醇血症患者的血清TSH平均显著高于对照者，即使排除AAB呈阳性的患者也是如此。TC与血清TSH之间存在显著相关性。结论是，甲状腺功能减退可能不是一种全或无的现象，许多甲状腺检查在传统正常范围内的高胆固醇血症患者可能存在轻微的甲状腺功能损害。
