对促甲状腺激素释放激素反应过度：冠心病女性的一个风险因素。
Exaggerated responsiveness to thyrotrophin releasing hormone: a risk factor in women with coronary artery disease.
作者信息
Dean J W, Fowler P B
出版信息
Br Med J (Clin Res Ed). 1985 May 25;290(6481):1555-61. doi: 10.1136/bmj.290.6481.1555.
Thyroid function tests were performed and thyroid antibodies and serum cholesterol concentrations measured in 12 women aged 60 years or under with severe coronary artery disease proved by coronary angiography. This group was compared with 11 women with normal coronary angiography. Ten out of the 12 women with coronary artery disease had an exaggerated response of thyroid stimulating hormone to thyrotrophin releasing hormone compared with two out of 11 controls (p less than 0.008). The mean serum cholesterol concentration was significantly higher in those with coronary artery disease than in the controls. Thyroid antibodies were present in four of those with coronary artery disease and one of the controls. There was no difference in the risk factors for coronary artery disease between the two groups except for cigarette smoking. Eleven out of 12 in the coronary artery disease group smoked cigarettes compared with four out of 11 in the control group (p less than 0.01). Minimal impairment of thyroid function is an important risk factor for coronary artery disease in women.
对12名60岁及以下经冠状动脉造影证实患有严重冠状动脉疾病的女性进行了甲状腺功能测试，并检测了甲状腺抗体和血清胆固醇浓度。将该组与11名冠状动脉造影正常的女性进行比较。与11名对照组中的2名相比，12名患有冠状动脉疾病的女性中有10名对促甲状腺激素释放激素的促甲状腺激素反应过度（p<0.008）。患有冠状动脉疾病的患者的平均血清胆固醇浓度显著高于对照组。12名患有冠状动脉疾病的患者中有4名存在甲状腺抗体，对照组中有1名存在甲状腺抗体。除吸烟外，两组之间冠状动脉疾病的危险因素没有差异。冠状动脉疾病组中12人中有11人吸烟，而对照组中11人中有4人吸烟（p<0.01）。甲状腺功能的轻微损害是女性冠状动脉疾病的一个重要危险因素。
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