Synthesis and antibacterial activity of novel oxazolidinones with methylene oxygen- and methylene sulfur-linked substituents at C5-position.
作者信息
Rudra Sonali, Sangita Fnu, Gujrati Arti, Pandya Manisha, Bhateja Pragya, Mathur Tarun, Singhal Smita, Rattan Ashok, Salman Mohammed, Das Biswajit
机构信息
Department of Medicinal Chemistry, New Drug Discovery Research, Ranbaxy Laboratories Limited, Plot-20, Sector-18, Udyog Vihar, Gurgaon, India.
出版信息
Bioorg Med Chem Lett. 2007 Sep 1;17(17):4778-83. doi: 10.1016/j.bmcl.2007.06.056. Epub 2007 Jun 26.
PMID:17618116
Abstract
Novel oxazolidinone derivatives of the lead compound RBx 8700, containing methylene oxygen- and methylene sulfur-linked substituents at the C5-position, were synthesized. Antibacterial screening of these compounds against a panel of resistant and susceptible Gram-positive and fastidious Gram-negative bacteria gave compounds 2 and 4 as new antibacterial agents.
摘要
Zotero 插件