Avşar Aysun, Elli Murat, Darka Ozge, Pinarli Güçlü
Department of Pediatric Dentistry, Faculty of Dentistry, University of Ondokuz Mayis, Samsun, Turkey.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Dec;104(6):781-9. doi: 10.1016/j.tripleo.2007.02.029. Epub 2007 Jul 6.
The aim of this study was to investigate the long-term effects of chemotherapy on oral health and dental development in childhood cancer survivors (CCS).
Ninety-six CCS patients with a mean age of 10.8 years and 96 healthy children of the same age and sex and social background composed the study group. The caries experience of the children was recorded according to the criteria of the World Health Organization, and plaque-gingival status was evaluated according to the Silness-Loe Index. The children were also investigated for stimulated salivary flow rate, buffer capacity, salivary mutans streptococci, and lactobacilli. Disturbances of enamel mineralization were recorded according to the index of developmental defects in dental enamel. Dental development disturbances were diagnosed on panoramic radiographs.
The caries experience, mutans streptococci, and lactobacilli colonization in CCS children were found significantly higher than in the healthy subjects (P < .05). White/cream colored opacities were the most frequent enamel mineralization disturbances (69.8 %). The occurrence of arrested root development with short V-shaped root malformation was significantly higher in CCS children than in the healthy subjects (P < .05). No statistically significant difference was found between group <or=5 years and >5 years.
This current investigation has shown that CCS children are at an increased risk of caries and developmental dental disturbances.
本研究旨在调查化疗对儿童癌症幸存者（CCS）口腔健康和牙齿发育的长期影响。
研究组由96名平均年龄为10.8岁的CCS患者以及96名年龄、性别和社会背景相同的健康儿童组成。根据世界卫生组织的标准记录儿童的龋齿经历，并根据Silness-Loe指数评估菌斑-牙龈状况。还对儿童的刺激唾液流速、缓冲能力、变形链球菌和乳酸菌进行了调查。根据牙釉质发育缺陷指数记录牙釉质矿化紊乱情况。通过全景X线片诊断牙齿发育紊乱。
发现CCS儿童的龋齿经历、变形链球菌和乳酸菌定植情况显著高于健康受试者（P < 0.05）。白色/奶油色不透明是最常见的牙釉质矿化紊乱（69.8%）。CCS儿童中出现短V形根畸形的牙根发育停滞的发生率显著高于健康受试者（P < 0.05）。在≤5岁组和>5岁组之间未发现统计学上的显著差异。
本次调查表明，CCS儿童患龋齿和牙齿发育紊乱的风险增加。
