Näsman M, Björk O, Söderhäll S, Ringdén O, Dahllöf G
Department of orthodontics and pediatric dentistry, Karolinska Institute, Stockholm, Sweden.
Pediatr Dent. 1994 May-Jun;16(3):217-23.
Oral health and disturbances in dental development were studied in long-term survivors after antineoplastic therapy. Fifty-seven children treated with combination chemotherapy and 19 children treated with total body irradiation (TBI) prior to bone marrow transplantation (BMT) were examined. The variables studied were dental caries, salivary flow, salivary microbial counts, enamel disturbances, and disturbances in dental development. The results showed no increased caries experience in children treated with BMT or chemotherapy compared with controls. Children treated with BMT had a significantly lower salivary secretion rate of 0.7 +/- 0.4 ml/min, compared with 1.1 +/- 0.5 in the chemotherapy group, and 1.3 +/- 0.6 in the control group (P < 0.05). The clinical examination showed equal numbers of teeth affected by disturbances in enamel mineralization in the BMT and chemotherapy groups. A mean 15.9 +/- 8.2 teeth were affected by disturbances in root development in the BMT group compared with 1.2 +/- 1.6 in the chemotherapy group (P < 0.001). The results show that children who are long-term survivors of pediatric malignant diseases exhibit a wide range of disturbances in the oral cavity. In this study the most severe disturbances are found in children treated with total body irradiation prior to BMT.
对接受抗肿瘤治疗后的长期存活者的口腔健康和牙齿发育障碍进行了研究。检查了57名接受联合化疗的儿童和19名在骨髓移植（BMT）前接受全身照射（TBI）的儿童。所研究的变量包括龋齿、唾液流量、唾液微生物计数、牙釉质紊乱和牙齿发育障碍。结果显示，与对照组相比，接受BMT或化疗的儿童龋齿发生率并未增加。接受BMT治疗的儿童唾液分泌率显著降低，为0.7±0.4毫升/分钟，化疗组为1.1±0.5毫升/分钟，对照组为1.3±0.6毫升/分钟（P<0.05）。临床检查显示，BMT组和化疗组中受牙釉质矿化紊乱影响的牙齿数量相同。BMT组平均有15.9±8.2颗牙齿受牙根发育障碍影响，化疗组为1.2±1.6颗（P<0.001）。结果表明，小儿恶性疾病的长期存活儿童口腔中存在广泛的紊乱。在本研究中，最严重的紊乱出现在BMT前接受全身照射的儿童中。
