使用自体骨或骨替代物联合富血小板血浆进行窦底提升术。
Sinus floor elevation using autogenous bone or bone substitute combined with platelet-rich plasma.
作者信息
Schlegel Karl Andreas, Zimmermann Robert, Thorwarth Michael, Neukam Friedrich-Wilhelm, Klongnoi Boworn, Nkenke Emeka, Felszeghy Endre
机构信息
Department of Oral Maxillofacial Surgery, Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Sep;104(3):e15-25. doi: 10.1016/j.tripleo.2007.04.021. Epub 2007 Jul 6.
OBJECTIVE
Sinus augmentation is a common approach for patients with severe alveolar ridge atrophy. However, autogenous bone sometimes results in donor site complications. Bone substitutes with platelet-rich plasma (PRP) promote early bone formation with autogenous bone. Use of PRP on autogenous bone and a bovine bone substitute were investigated in this split-mouth animal study.
STUDY DESIGN
Premolars were extracted from minipigs. Each animal received sinus augmentation using a lateral approach with simultaneous insertion of 3 implants in each site. Groups were randomized using autogenous bone alone and combined with PRP or a bovine hydroxyapatite alone in combination with PRP.
RESULTS
Microradiographic findings in the autogenous group did not show significantly different rates by using autogenous bone alone or combined with PRP. Using the bovine hydroxyapatite as augmentation material only at 8 weeks, a nonsignificant effect in the PRP group could be seen. At all other observation periods, no significant influence was observed.
CONCLUSION
No significant influence of PRP was found.
目的
上颌窦提升术是严重牙槽嵴萎缩患者的常用治疗方法。然而，自体骨有时会导致供区并发症。富含血小板血浆（PRP）的骨替代物可促进自体骨早期骨形成。本双盲动物研究对自体骨和牛骨替代物使用PRP进行了研究。
研究设计
从小型猪中拔除前磨牙。每只动物均采用外侧入路进行上颌窦提升术，每个部位同时植入3颗种植体。分组随机采用单独使用自体骨、自体骨联合PRP或单独使用牛羟基磷灰石联合PRP。
结果
自体骨组的显微放射学结果显示，单独使用自体骨或联合PRP的骨形成率无显著差异。仅在8周时使用牛羟基磷灰石作为增强材料，PRP组可见无显著影响。在所有其他观察期，未观察到显著影响。
结论
未发现PRP有显著影响。
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