结直肠癌和前列腺癌的一种常见遗传风险因素。
A common genetic risk factor for colorectal and prostate cancer.
作者信息
Haiman Christopher A, Le Marchand Loïc, Yamamato Jennifer, Stram Daniel O, Sheng Xin, Kolonel Laurence N, Wu Anna H, Reich David, Henderson Brian E
机构信息
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA.
出版信息
Nat Genet. 2007 Aug;39(8):954-6. doi: 10.1038/ng2098. Epub 2007 Jul 8.
Abstract
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 x 10(-6)) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
摘要
8号染色体q24区域的变异会增加患前列腺癌的风险；在此，我们测试了这些变异是否也会调节患结直肠癌的风险。我们研究了1807名患者和5511名对照，发现其中一个变异rs6983267也与结直肠癌显著相关（优势比=1.22；P=4.4×10⁻⁶），并且两种癌症之间变异风险的分配存在显著差异。该区域的综合检测发现了一些变异，这些变异带来了显著的额外风险。我们的结果表明，8q24区域的变异对癌症发展的影响因组织类型而异。
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