Vanan Ahmad Ghorbani, Ghorbaninezhad Farid, Nikeghbali Golnaz, Mohamadi Fateme, Ayati Ariyan, Mastani Reza Ghanbari, Shahhoseini Zahra, Eini Pooya, Ahmadi Ronak, Tahmasebi Safa, Safarzadeh Elham
Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Exp Med. 2025 Jun 11;25(1):197. doi: 10.1007/s10238-025-01730-y.
Long non-coding RNAs (lncRNAs) are a class of non-protein-coding RNAs that have over 200 nucleotides. Various studies have shown that aberrant expression of lncRNAs can lead to the development of different tumors. Furthermore, recent findings revealed that abnormal lncRNA expression can significantly influence cancer-related processes such as proliferation, migration, invasion, metastasis, and epithelial-mesenchymal transition. Colon cancer-associated transcript 2 (CCAT2), a type of lncRNA, was initially identified as an oncogene in colon cancer and subsequently identified as a prognostic biomarker in different cancers, including hepatocellular carcinoma, esophageal squamous cell carcinoma, ovarian cancer, lung cancer, breast cancer, and other tumors. Cumulative studies have revealed that the overexpression of CCAT2 is significantly correlated with tumor size, tumor node metastasis (TNM stage), tumor progression, and poor clinical outcomes. The significant role of CCAT2 in various gastrointestinal (GI) malignancies has drawn increased attention in recent years. In the present study, we reviewed recent literature concerning lncRNA CCAT2's role in the development and progression of different GI cancers, including colorectal, gastric, hepatocellular, and oropharyngeal cancer, its interaction with cancer-related molecular mechanisms, and evaluate its potential as a diagnostic and prognostic biomarker in GI patients. In addition, this study shows that CCAT2 can be applied as a novel target for treatment strategies in gastrointestinal cancers.
长链非编码RNA（lncRNAs）是一类具有超过200个核苷酸的非蛋白质编码RNA。各种研究表明，lncRNAs的异常表达可导致不同肿瘤的发生。此外，最近的研究结果显示，lncRNA表达异常可显著影响癌症相关过程，如增殖、迁移、侵袭、转移和上皮-间质转化。结肠癌相关转录本2（CCAT2）是一种lncRNA，最初被鉴定为结肠癌中的一种癌基因，随后被确定为包括肝细胞癌、食管鳞状细胞癌、卵巢癌、肺癌、乳腺癌和其他肿瘤在内的不同癌症的预后生物标志物。累积研究表明，CCAT2的过表达与肿瘤大小、肿瘤淋巴结转移（TNM分期）、肿瘤进展和不良临床结局显著相关。近年来，CCAT2在各种胃肠道（GI）恶性肿瘤中的重要作用受到了越来越多的关注。在本研究中，我们回顾了有关lncRNA CCAT2在不同胃肠道癌症（包括结直肠癌、胃癌、肝细胞癌和口咽癌）的发生和进展中的作用、其与癌症相关分子机制的相互作用的近期文献，并评估其作为胃肠道疾病患者诊断和预后生物标志物的潜力。此外，本研究表明，CCAT2可作为胃肠道癌症治疗策略的新靶点。
