调节性T细胞中的转录伙伴：Foxp3、Runx和NFAT。

Transcriptional partners in regulatory T cells: Foxp3, Runx and NFAT.

作者信息

Hu Hui, Djuretic Ivana, Sundrud Mark S, Rao Anjana

机构信息

The CBR Institute for Biomedical Research and the Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

出版信息

Trends Immunol. 2007 Aug;28(8):329-32. doi: 10.1016/j.it.2007.06.006. Epub 2007 Jul 6.

DOI:10.1016/j.it.2007.06.006

PMID:17618833

Abstract

A general theme in gene regulation is that transcription factors never function alone. Recent studies have emphasized this concept for regulatory T cells, a unique lineage of CD4+ T cells that exert active immune suppression and are essential to maintaining self-tolerance.

摘要

基因调控的一个普遍主题是转录因子从不单独发挥作用。最近的研究强调了调节性T细胞的这一概念，调节性T细胞是CD4+T细胞的一个独特谱系，具有主动免疫抑制作用，对维持自身耐受性至关重要。