肥胖女性中内脂素的血清浓度。
Serum concentration of visfatin in obese women.
作者信息
Zahorska-Markiewicz Barbara, Olszanecka-Glinianowicz Magdalena, Janowska Joanna, Kocełak Piotr, Semik-Grabarczyk Elzbieta, Holecki Michał, Dabrowski Piotr, Skorupa Anna
机构信息
Department of Pathophysiology, Medical University of Silesia, 40-752 Katowice, Poland.
出版信息
Metabolism. 2007 Aug;56(8):1131-4. doi: 10.1016/j.metabol.2007.04.007.
The aim of the present study was to determine serum concentrations of visfatin in obese women in comparison to normal-weight controls. Study subjects were 21 obese women without additional disease (age, 29.0+/-4.9 years; body mass index, 37.1+/-6.1 kg/m2) and 16 healthy, normal-weight women (age, 29.9+/-5.4 years; body mass index, 22.5+/-1.7 kg/m2). Body composition was measured by bioimpedance. Serum concentrations of visfatin were assayed with an enzyme-linked immunosorbent assay kit (Phoenix Pharmaceuticals, Burlingame, CA). Insulin was determined by radioimmunoassay and glucose by colorimetric method. Serum concentration of visfatin was significantly higher in obese women when compared to controls. Positive correlations between serum concentrations of visfatin and insulin in the obese group were found. In the control group, we observed positive correlations between serum concentrations of visfatin and glucose. In conclusion, the observed increase of visfatin in obesity may be a counterregulation preventing further glucose increase.
本研究的目的是测定肥胖女性与正常体重对照者相比的内脂素血清浓度。研究对象为21名无其他疾病的肥胖女性（年龄29.0±4.9岁；体重指数37.1±6.1kg/m2）和16名健康的正常体重女性（年龄29.9±5.4岁；体重指数22.5±1.7kg/m2）。通过生物电阻抗测量身体成分。使用酶联免疫吸附测定试剂盒（Phoenix Pharmaceuticals，加利福尼亚州伯林盖姆）测定内脂素的血清浓度。通过放射免疫测定法测定胰岛素，通过比色法测定葡萄糖。与对照组相比，肥胖女性的内脂素血清浓度显著更高。在肥胖组中发现内脂素血清浓度与胰岛素之间呈正相关。在对照组中，我们观察到内脂素血清浓度与葡萄糖之间呈正相关。总之，在肥胖中观察到的内脂素增加可能是一种防止葡萄糖进一步升高的代偿调节。
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