Masaki H, Ide M, Mochinaga S, Kawachi Y, Fukuda K, Tsukamoto N, Watanabe K, Takahashi A, Nagatake T, Matsumoto K
Department of Internal Medicine, Nagasaki Rosai Hospital.
Kansenshogaku Zasshi. 1991 Sep;65(9):1205-10. doi: 10.11150/kansenshogakuzasshi1970.65.1205.
In Japan, we experienced the first case of Hafnia alvei septicemia with shock and disseminated intravascular coagulation (DIC) in an adult with postoperative lung cancer. A 63 year-old male, who had been followed up in our department since 1987, was admitted to our hospital with the complaints of fever, hemoptysis and dyspnea on June 25, 1989. After admission, he was treated with sulbactam/cefoperazone 4 g/day intravenously for suspicion of respiratory-tract infection. After antibiotic administration, the fever subsided and the general condition became almost good. The patient experienced fever again after the antibiotic was stopped. For this reason subsequent Clavulanic acid/Amoxicillin, Flomoxef, and Ceftazidime was administered, but was not effective. Therefore septicemia was suspected and blood culture was done. The bacteria isolated from blood culture was identified as Hafnia alvei. Hafnia alvei is a gram-negative organism belonging to the Enterobacteriaceae family and quite rare pathogen in human.
在日本，我们遇到了首例成人肺癌术后由蜂房哈夫尼亚菌引起的伴有休克和弥散性血管内凝血（DIC）的败血症病例。一名63岁男性，自1987年起在我院接受随访，于1989年6月25日因发热、咯血和呼吸困难入院。入院后，因怀疑呼吸道感染，给予舒巴坦/头孢哌酮4克/天静脉滴注治疗。抗生素治疗后，发热消退，一般状况基本好转。停用抗生素后患者再次发热。因此随后给予克拉维酸/阿莫西林、氟氧头孢和头孢他啶治疗，但均无效。于是怀疑败血症并进行了血培养。从血培养中分离出的细菌被鉴定为蜂房哈夫尼亚菌。蜂房哈夫尼亚菌是一种革兰氏阴性菌，属于肠杆菌科，是人类中相当罕见的病原体。
