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以小脑肿块为表现的神经结节病。

Neurosarcoidosis presenting as a cerebellar mass.

作者信息

Kumar Gautam, Kang Caroline A, Giannini Caterina

机构信息

Department of Internal Medicine, Mayo Clinic, 200 2nd Street SW, Rochester, MN 55905, USA.

出版信息

J Gen Intern Med. 2007 Sep;22(9):1373-6. doi: 10.1007/s11606-007-0272-7. Epub 2007 Jul 6.

Abstract

CASE REPORT

A 74-year-old farmer presented with worsening headaches, gait unsteadiness, and writing difficulties. On examination, he had a tendency to fall to the right and right-sided dysmetria and dysdiadochokinesis. Magnetic resonance imaging initially showed abnormalities in the right cerebellar hemisphere, suggestive of subacute infarct or infiltrating malignancy. Suboccipital craniotomy and biopsy revealed noncaseating granulomas suggestive of sarcoidosis. He was initially treated with steroids and later switched to Infliximab. On follow-up 5 months later, symptoms and imaging had improved.

DISCUSSION

Sarcoidosis affects the central nervous system in about 5% of patients. It usually manifests with cranial nerve palsies. It may rarely mimic a tumor as in this patient. Despite the dearth of controlled studies addressing neurosarcoidosis treatment, excellent responses to corticosteroids have been documented. Infliximab has been used as a steroid-sparing agent in neurosarcoidosis. We present this case of neurosarcoidosis presenting as a cerebellar mass to increase awareness of this condition.

摘要

病例报告

一名74岁的农民出现头痛加剧、步态不稳和书写困难。检查发现,他有向右倾倒的倾向,右侧存在辨距不良和轮替运动障碍。磁共振成像最初显示右侧小脑半球有异常,提示亚急性梗死或浸润性恶性肿瘤。枕下开颅手术及活检显示为非干酪样肉芽肿,提示结节病。他最初接受类固醇治疗,后来改用英夫利昔单抗。5个月后的随访显示,症状和影像学表现均有改善。

讨论

结节病在约5%的患者中会累及中枢神经系统。其通常表现为颅神经麻痹。像该患者这样极少情况下可能类似肿瘤。尽管针对神经结节病治疗的对照研究较少,但已有文献记载对皮质类固醇有良好反应。英夫利昔单抗已被用作神经结节病的类固醇替代药物。我们呈现这例表现为小脑肿块的神经结节病病例,以提高对这种疾病的认识。

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