Giraldi Cristina, Noto Alessandra, Tenuta Robert, Greco Francesca, Perugini Daniela, Dodaro Saveria, Spadafora Mario, Lo Bianco Anna Maria, Savino Olga, Papalia Teresa, Greco Rosita, Bonofiglio Renzo
Laboratorio di Microbiologia e Virologia, PO "Annunziata" AO, Cosenza, Italy.
New Microbiol. 2007 Apr;30(2):127-30.
Nephropathy caused by poliomavirus (BKVAN) in transplant recipients is responsible for the loss of the transplanted organ. In this study we suggest a non-invasive diagnostic protocol for the early identification of BKVAN during follow-up treatments. In 117 kidney transplant recipients follow-up was performed every three months during a two year period after transplantation and a positive screening result was confirmed and assessed by quantitative assays (BKV DNA load in plasma and urine). The definitive diagnosis of BKV requires allograft biopsy. Of the 117 patients 4 had BKVAN (3.4%), and the consequential reduction of immunosuppression improved kidney function and plasma clearance of the virus was achieved.
移植受者中由多瘤病毒（BK病毒相关性肾病，BKVAN）引起的肾病是移植器官丧失的原因。在本研究中，我们提出了一种非侵入性诊断方案，用于在后续治疗期间早期识别BKVAN。在117名肾移植受者中，移植后两年期间每三个月进行一次随访，并通过定量检测（血浆和尿液中的BK病毒DNA载量）确认和评估筛查阳性结果。BK病毒的确诊需要进行移植肾活检。117名患者中有4名患有BKVAN（3.4%），通过减少免疫抑制，肾功能得到改善，病毒的血浆清除率也得以实现。
