Nakashima T, Tanaka M, Okamura S
Department of Otolaryngology, National Kyushu Cancer Centre, Fukuoka, Japan.
J Laryngol Otol. 1991 Nov;105(11):939-45. doi: 10.1017/s0022215100117864.
Serum levels of immunosuppressive acidic protein (IAP) and other immunological parameters were examined in 95 head and neck cancer patients and 27 control patients. The mean values of IAP in patients in the advanced stage were significantly higher than in early stage patients. Statistically significant increases in the mean concentration of IAP were also observed in patients with a recurrence, as compared to findings in those in the advanced stages. The mean values of blastogenesis response to PHA and NK cell activity in the cancer patients were lower than in disease free individuals, but with no statistical differences. In the endstage patients, the IAP concentration was considerably elevated and the blastogenesis response showed a statistically significant decrease. Thus, the monitoring of serum IAP, in combination with other immunological parameters, aids in planning and assessing clinical staging in head and neck cancer patients.
检测了95例头颈癌患者和27例对照患者血清中免疫抑制酸性蛋白（IAP）水平及其他免疫参数。晚期患者IAP的平均值显著高于早期患者。与晚期患者相比，复发患者IAP的平均浓度也有统计学意义的升高。癌症患者对PHA的增殖反应平均值和NK细胞活性低于无病个体，但无统计学差异。终末期患者IAP浓度显著升高，增殖反应有统计学意义的降低。因此，监测血清IAP并结合其他免疫参数，有助于对头颈癌患者进行临床分期的规划和评估。
