低分子量肝素和氨基己酸在前列腺癌相关慢性弥散性血管内凝血中的应用——病例报告
Use of low molecular weight heparin and aminocaproic acid in chronic DIC associated with prostate cancer--a case report.
作者信息
Shirai Keisuke, Chaudhary Uzair B
机构信息
Department of Medicine, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA.
出版信息
ScientificWorldJournal. 2007 Feb 2;7:753-5. doi: 10.1100/tsw.2007.143.
Disseminated Intravascular Coagulopathy (DIC) is the most common coagulopathy in patients with prostate cancer. Though rare, it could be fatal without treatment. Literature suggests that there is significant activation of fibrinolytic pathway. Pathophysiology of DIC in patients with prostate cancer is not completely understood. We present here a case of chronic DIC in a patient with metastatic androgen independent prostate cancer. His DIC was managed successfully with a combination of aminocaproic acid and low weight molecular heparin. The use of low molecular weight heparin may make management of chronic DIC in prostate cancer more feasible in an out patient setting.
弥散性血管内凝血（DIC）是前列腺癌患者中最常见的凝血障碍。虽然罕见，但如不治疗可能致命。文献表明，纤维蛋白溶解途径有显著激活。前列腺癌患者DIC的病理生理学尚未完全明了。我们在此呈现一例转移性雄激素非依赖性前列腺癌患者的慢性DIC病例。他的DIC通过氨基己酸和低分子量肝素联合治疗成功得到控制。低分子量肝素的使用可能使门诊环境下前列腺癌慢性DIC的管理更可行。
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