体外成纤维细胞对通过严重塑性变形工艺制备的超细晶粒钛的反应。
In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process.
作者信息
Kim Taik Nam, Balakrishnan A, Lee B C, Kim W S, Dvorankova B, Smetana K, Park J K, Panigrahi B B
机构信息
Department of Information and Electronic Materials Engineering, Paichai University, Daejeon, Korea.
出版信息
J Mater Sci Mater Med. 2008 Feb;19(2):553-7. doi: 10.1007/s10856-007-3204-5. Epub 2007 Jul 10.
The in vitro response of the mouse fibroblast cell line 3T3 on the surface of ultrafine grained titanium [produced by a severe plastic deformation (SPD) process] has been studied in this work. SPD Ti showed much higher strength than the coarse grained Ti and equivalent to that of Ti-6Al-4V alloy. Better cell proliferation was observed on SPD Ti compared to conventional Ti and Ti-6Al-4V alloy. This could be attributed to the increased surface free energy by reduction in the grain size and possibly the presence of a large number of nano size grooves at the triple point junctions in SPD Ti sample. There was no significant difference in the results of cytotoxicity tests of fine and coarse grained materials.
在本研究中，对小鼠成纤维细胞系3T3在超细晶粒钛（通过严重塑性变形（SPD）工艺制备）表面的体外反应进行了研究。SPD钛的强度比粗晶粒钛高得多，与Ti-6Al-4V合金相当。与传统钛和Ti-6Al-4V合金相比，在SPD钛上观察到更好的细胞增殖。这可能归因于晶粒尺寸减小导致表面自由能增加以及SPD钛样品中三相交界处可能存在大量纳米尺寸的沟槽。细晶粒和粗晶粒材料的细胞毒性测试结果没有显著差异。
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