El Briak Hasna, Durand Denis, Boudeville Philippe
Faculté de Pharmacie, Centre de Recherche sur les Biopolymères Artificiels, IBMM UMR CNRS 5247, 15 Avenue Charles Flahault, Montpellier Cedex 5, France.
J Mater Sci Mater Med. 2008 Feb;19(2):737-44. doi: 10.1007/s10856-007-3198-z. Epub 2007 Jul 10.
A CPC was obtained by mixing calcium hydrogenphosphate (DCPA: CaHPO(4)) and calcium oxide with either water or sodium phosphate (NaP) buffers. Physical and mechanical properties such as compressive strength (CS), initial (I) and final (F) setting times, cohesion time (T(C)), dough time (T(D)), swelling time (T(S)), dimensional and thermal behavior, injectability (t(100%)), antimicrobial properties, setting reaction kinetics, and powder stability over time were investigated by varying different parameters such as liquid-to-powder (L/P) ratio (0.35 to 0.7 mL g(-1)), molar calcium-to-phosphate (Ca/P) ratio (1.67 to 3), the pH (4, 7 or 9) and the concentration (0 to 1 M) of the NaP buffer. The best results were obtained with the pH 7 NaP buffer at a concentration of 0.75 M. With this liquid phase, physical and mechanical properties depended on the Ca/P and L/P ratios, varying from 3 to 11 MPa (CS), 6 to 10 min (I), 11 to 15 min (F), 15 to 45 min (T(S)), 3 to 12 min (t(100%)), 16 min (T(D)). This cement expanded during its setting (2.5-7%), and is thus appropriate for tight filling. Finally the cement has antimicrobial activity from Ca/P = 2 and the whole properties were conserved after 8 months storage. Given the mechanical, rheological and antimicrobial properties of this new DCPA/CaO-based cement, its use as root canal sealing or pulp capping material may be considered as similar to calcium hydroxide or ZnO/eugenol-based pastes, without or with a gutta-percha point.
通过将磷酸氢钙（磷酸二钙：CaHPO₄）和氧化钙与水或磷酸钠（NaP）缓冲液混合来制备磷酸钙骨水泥（CPC）。通过改变不同参数，如液固比（L/P）（0.35至0.7 mL g⁻¹）、钙磷摩尔比（Ca/P）（1.67至3）、pH值（4、7或9）以及NaP缓冲液的浓度（0至1 M），研究了抗压强度（CS）、初凝（I）和终凝（F）时间、凝聚时间（T(C)）、面团时间（T(D)）、膨胀时间（T(S)）、尺寸和热行为、可注射性（t(100%)）、抗菌性能、凝固反应动力学以及粉末随时间的稳定性等物理和机械性能。在浓度为0.75 M的pH 7 NaP缓冲液中获得了最佳结果。使用这种液相时，物理和机械性能取决于Ca/P和L/P比，抗压强度为3至11 MPa（CS），初凝时间为6至10分钟（I），终凝时间为11至15分钟（F），膨胀时间为15至45分钟（T(S)），可注射时间为3至12分钟（t(100%)），面团时间为16分钟（T(D)）。这种骨水泥在凝固过程中会膨胀（2.5 - 7%），因此适合紧密填充。最后，当Ca/P = 2时该骨水泥具有抗菌活性，并且在储存8个月后所有性能保持不变。鉴于这种新型基于磷酸二钙/氧化钙的骨水泥的机械、流变学和抗菌性能，可考虑将其用作根管封闭或牙髓盖髓材料，类似于氢氧化钙或氧化锌/丁香酚基糊剂，有无牙胶尖均可。
