Tan Chun-Hong, Li Jian, Nation Roger L
Facility for Anti-infective Drug Development and Innovation, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Antimicrob Agents Chemother. 2007 Sep;51(9):3413-5. doi: 10.1128/AAC.01571-06. Epub 2007 Jul 9.
Three clinically relevant intermittent regimens, and a continuous infusion, of colistin were simulated in an in vitro pharmacokinetic/pharmacodynamic model against two colistin-heteroresistant strains of Acinetobacter baumannii. Extensive initial killing was followed by regrowth as early as 6 h later; bacterial density in the 24- to 72-h period was within 1 log(10) CFU/ml of growth control. Population analysis profiles revealed extensive emergence of resistant subpopulations regardless of the colistin regimen.
在体外药代动力学/药效学模型中，针对两种对黏菌素具有异质性耐药的鲍曼不动杆菌菌株，模拟了三种具有临床相关性的间歇性给药方案以及持续输注黏菌素的情况。在最初出现广泛的杀菌作用后，最早在6小时后细菌开始重新生长；在24至72小时期间的细菌密度与生长对照相比，相差在1个对数（10）CFU/ml以内。群体分析图谱显示，无论黏菌素的给药方案如何，耐药亚群都会大量出现。
