Diette Gregory B, Patino Cecilia M, Merriman Barry, Paulin Laura, Riekert Kristin, Okelo Sande, Thompson Kathy, Krishnan Jerry A, Quartey Ruth, Perez-Williams Deanna, Rand Cynthia
Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 1830 E Monument St, Fifth Floor, Baltimore, MD 21205, USA.
Arch Intern Med. 2007 Jul 9;167(13):1360-6. doi: 10.1001/archinte.167.13.1360.
Asthma guidelines recommend severity assessment to assign treatment, often quantified as current control. It is unknown how strongly control assessment affects clinician treatment decisions, nor if control is sufficient.
To determine patient factors used by physicians to assign treatment, we surveyed pulmonary specialists (PSs) and family physicians (FPs) using vignettes. We tested whether recent acute care (hospitalization 6 months ago), bother (patient bothered by asthma), control (symptom or reliever medication frequency), and direction (change since last visit) influence treatment decisions. Factors used for stepping up and stepping down were assessed.
A total of 461 physicians participated (236 PSs and 225 FPs). As expected, physicians indicated a greater likelihood of stepping up treatment for persistent (4-5 times per week) than for intermittent (1 time per 2 weeks) symptoms (PSs 97% vs 24%, P < .001; FPs 97% vs 33%, P < .001). All else being equal, physicians were more likely to step up treatment of a patient with intermittent symptoms if the patient reported recent acute care (PSs 49% vs 24%; FPs 72% vs 33%), was bothered (PSs 81% vs 24%; FPs 80% vs 33%), or was worse since the last visit (PSs 68% vs 24%; FPs 66% vs 33%) (all P < .001). These factors were also predictive of stepping down from high-intensity therapy and remained significant in multivariate analyses (all P < .05).
Asthma control greatly influences physician decisions about asthma treatments. However, recent acute care, bother, and direction of illness also influence decisions, particularly those that involve increasing the amount of medication prescribed. Further work is needed to determine if use of these additional indicators leads to better asthma outcomes.
哮喘指南建议进行严重程度评估以确定治疗方案,通常以当前控制情况进行量化。目前尚不清楚控制情况评估对临床医生治疗决策的影响程度,也不清楚控制是否足够。
为了确定医生用于确定治疗方案的患者因素,我们使用病例 vignettes 对肺科专家(PSs)和家庭医生(FPs)进行了调查。我们测试了近期急性护理(6个月前住院)、困扰程度(患者受哮喘困扰情况)、控制情况(症状或缓解药物使用频率)以及病情变化方向(自上次就诊以来的变化)是否会影响治疗决策。评估了用于增加和减少治疗强度的因素。
共有461名医生参与(236名肺科专家和225名家庭医生)。正如预期的那样,医生表示对于持续性症状(每周4 - 5次)的患者增加治疗的可能性大于间歇性症状(每2周1次)的患者(肺科专家:97%对24%,P <.001;家庭医生:97%对33%,P <.001)。在其他条件相同的情况下,如果患者报告近期有急性护理(肺科专家:49%对24%;家庭医生:72%对33%)、受到困扰(肺科专家:81%对24%;家庭医生:80%对33%)或自上次就诊以来病情恶化(肺科专家:68%对24%;家庭医生:66%对33%),医生更有可能对有间歇性症状的患者增加治疗(所有P <.001)。这些因素也可预测从高强度治疗方案中减少用药,并且在多变量分析中仍然具有显著性(所有P <.05)。
哮喘控制情况对医生关于哮喘治疗的决策有很大影响。然而,近期急性护理、困扰程度和病情变化方向也会影响决策,特别是那些涉及增加处方药物剂量的决策。需要进一步开展工作以确定使用这些额外指标是否能带来更好的哮喘治疗效果。