Wang Chin-Chou, Liu Shih-Feng, Liao Shang-Chih, Lee Ing-Kit, Liu Jien-Wei, Lin An-Shen, Wu Chao-Chien, Chung Yu-Hsiu, Lin Meng-Chih
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan, Republic of China.
Am J Trop Med Hyg. 2007 Jul;77(1):151-8.
To investigate clinical course and outcome of dengue with acute respiratory failure (ARF), and to identify related risk factors for acquiring ARF in dengue, we retrospectively studied 11 dengue patients with ARF. From June to December 2002, a total of 606 adult patients were diagnosed as having dengue. Eleven (1.8%) of 606 dengue patients had complications of ARF. The main causes of ARF were sepsis (n = 6, 54.5%) and upper gastrointestinal (UGI) bleeding (n = 3, 27.3%). The mortality rate was 72.7% (n = 8). Additionally, univariate analysis showed that age, dyspnea, cough, prothrombin time, activated partial thromboplastin time, aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, albumin, renal insufficiency, acute renal failure, acute hepatic failure, UGI bleeding, and combination bacterial infection were significantly predictive variables associated with dengue patients with ARF.
为研究登革热合并急性呼吸衰竭（ARF）的临床病程及结局，并确定登革热患者发生ARF的相关危险因素，我们对11例登革热合并ARF患者进行了回顾性研究。2002年6月至12月，共有606例成年患者被诊断为登革热。606例登革热患者中有11例（1.8%）出现ARF并发症。ARF的主要原因是脓毒症（n = 6，54.5%）和上消化道（UGI）出血（n = 3，27.3%）。死亡率为72.7%（n = 8）。此外，单因素分析显示，年龄、呼吸困难、咳嗽、凝血酶原时间、活化部分凝血活酶时间、天冬氨酸转氨酶、丙氨酸转氨酶、血尿素氮、肌酐、白蛋白、肾功能不全、急性肾衰竭、急性肝衰竭、UGI出血以及合并细菌感染是与登革热合并ARF患者相关的显著预测变量。
