Chen Shou-Chien, Chang Hsiao-Ling, Yan Tsong-Rong, Cheng Yan-Tzong, Chen Kow-Tong
Department of Family Medicine, Taipei City Hospital, Taipei, Taiwan, Republic of China.
Am J Trop Med Hyg. 2007 Jul;77(1):188-91.
In 1998, an epidemic of enterovirus 71 (EV 71) infection occurred in Taiwan. The purpose of this study was to assess the epidemiology of EV 71 infection in Taiwan. Between March 1998 and December 2005, a total of 1,548 severe cases of hand-foot-mouth disease and herpangina (HFMD/HA) was reported to the Center for Disease Control in Taiwan. A seasonal variation in number of severe cases was observed, with the annual peak in second quarter. Deaths from severe HFMD/HA varied from year to year (chi(2) for trend = 6.781, P = 0.009). Most (92%) cases occurred in children </= 4 years of age. Children infected with EV 71 had higher risk of pulmonary edema/hemorrhage and encephalitis than those not infected. Infection with EV 71 has emerged as an important infectious disease causing serious clinical illness and deaths of young children. Vaccine development is recommended to prevent future EV 71 infections.
1998年，台湾发生了肠道病毒71型（EV 71）感染疫情。本研究的目的是评估台湾地区EV 71感染的流行病学情况。1998年3月至2005年12月期间，台湾疾病控制中心共报告了1548例严重手足口病和疱疹性咽峡炎（HFMD/HA）病例。观察到严重病例数存在季节性变化，年度高峰出现在第二季度。严重HFMD/HA的死亡人数逐年不同（趋势检验χ² = 6.781，P = 0.009）。大多数（92%）病例发生在4岁及以下儿童。感染EV 71的儿童发生肺水肿/出血和脑炎的风险高于未感染者。EV 71感染已成为导致幼儿严重临床疾病和死亡的重要传染病。建议研发疫苗以预防未来的EV 71感染。
