Shimizu H, Utama A, Yoshii K, Yoshida H, Yoneyama T, Sinniah M, Yusof M A, Okuno Y, Okabe N, Shih S R, Chen H Y, Wang G R, Kao C L, Chang K S, Miyamura T, Hagiwara A
Department of Virology II, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
Jpn J Infect Dis. 1999 Feb;52(1):12-5.
Enterovirus 71 (EV71), one of the major causative agents for hand, foot and mouth disease (HFMD), is sometimes associated with severe central nervous system diseases. In 1997, in Malaysia and Japan, and in 1998 in Taiwan, there were HFMD epidemics involving sudden deaths among young children, and EV71 was isolated from the HFMD patients, including the fatal cases. The nucleotide sequences of each EV71 isolate were determined and compared by phylogenetical analysis. EV71 strains from previously reported epidemics belonged to genotype A-1, while those from recent epidemics could be divided into two genotypes, A-2 and B. In Malaysia, genotype A-2 was more prevalent, while in Japan and Taiwan, B genotype was more prevalent. Two isolates from fatal cases in Malaysia and one isolate from a fatal case in Japan were genotype A-2. However, all isolates from three fatal cases in Taiwan belonged to genotype B. The severity of the HFMD did not link directly to certain genotypes of EV71.
肠道病毒71型（EV71）是手足口病（HFMD）的主要病原体之一，有时与严重的中枢神经系统疾病有关。1997年，马来西亚和日本，以及1998年台湾地区，发生了手足口病疫情，涉及幼儿猝死，从包括致命病例在内的手足口病患者中分离出了EV71。通过系统发育分析确定并比较了每个EV71分离株的核苷酸序列。先前报告的疫情中的EV71毒株属于A-1基因型，而近期疫情中的毒株可分为两种基因型，A-2和B。在马来西亚，A-2基因型更为普遍，而在日本和台湾地区，B基因型更为普遍。马来西亚两例致命病例的分离株和日本一例致命病例的分离株为A-2基因型。然而，台湾地区三例致命病例的所有分离株均属于B基因型。手足口病的严重程度与EV71的某些基因型没有直接关联。
