Ansell Benjamin J, Fonarow Gregg C, Fogelman Alan M
Atherosclerosis Research Unit, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
Curr Opin Lipidol. 2007 Aug;18(4):427-34. doi: 10.1097/MOL.0b013e3282364a17.
This review addresses how, in atherosclerosis or systemic inflammation, HDL can lose its usual atheroprotective characteristics and even paradoxically assume proinflammatory properties.
Specific chemical and structural changes within HDL particles can impede reverse cholesterol transport, enhance oxidation of LDL, and increase vascular inflammation. HDL may be viewed as a shuttle that can be either anti-inflammatory or proinflammatory, depending on its cargo of proteins, enzymes, and lipids. Some therapeutic approaches that reduce coronary risk, such as statins and therapeutic lifestyle changes, can favorably moderate the characteristics of proinflammatory HDL. In addition, apolipoprotein A-I mimetic peptides and other compounds that target functional aspects of HDL may offer novel approaches to reduction in cardiovascular risk.
Current data suggest that under some conditions HDL can become dysfunctional and even proinflammatory, but this characterization can change with resolution of systemic inflammation or use of certain treatments.
本综述探讨在动脉粥样硬化或全身炎症状态下，高密度脂蛋白（HDL）如何丧失其通常的抗动脉粥样硬化保护特性，甚至反常地呈现促炎特性。
HDL颗粒内特定的化学和结构变化可阻碍胆固醇逆向转运、增强低密度脂蛋白（LDL）氧化并增加血管炎症。HDL可被视为一种穿梭载体，根据其所携带的蛋白质、酶和脂质成分，它既可能具有抗炎作用，也可能具有促炎作用。一些降低冠心病风险的治疗方法，如他汀类药物和治疗性生活方式改变，可有益地调节促炎HDL的特性。此外，载脂蛋白A-I模拟肽和其他针对HDL功能方面的化合物可能为降低心血管风险提供新方法。
目前的数据表明，在某些情况下HDL可能功能失调甚至具有促炎作用，但随着全身炎症的消退或使用某些治疗方法，这种特性可能会改变。
