血清氧化型低密度脂蛋白水平与冠心病患者缺血事件数量及血管损伤呈正相关。
Serum OxLDL Levels Are Positively Associated with the Number of Ischemic Events and Damaged Blood Vessels in Patients with Coronary Artery Disease.
作者信息
Perez-Robles Mariana, Campos-Perez Wendy, Godinez-Mora Sissi, Lopez-Alvarez Victor, Ramos-Villalobos Liliana Estefanía, Corona-Ruiz Felisardo, Armendariz-Borunda Juan, Martinez-Lopez Erika
机构信息
Instituto de Nutrigenética y Nutrigenómica Traslacional, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Doctorado en Ciencias de la Nutrición Traslacional, Departamento de la Reproducción Humana, Crecimiento y Desarrollo Infantil, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.
出版信息
Healthcare (Basel). 2025 Jun 14;13(12):1426. doi: 10.3390/healthcare13121426.
The severity of coronary artery disease (CAD) depends on several factors. Oxidative stress contributes to the oxidation of lipoproteins, thereby promoting ischemic events (IEs) and damaged blood vessels (DBVs). This study aimed to compare biochemical variables and levels of oxidized lipoproteins in CAD patients stratified by the number of IEs and DBVs. A cross-sectional study was performed, including 51 patients diagnosed with CAD. Serum oxidized lipoproteins were measured by ELISA. CAD patients with ≥2 IEs and ≥2 DBVs showed higher oxLDL levels than those with one IE and one DBV (8293.35 ng/mL [7131.32-9287.39] vs. 6474.26 ng/mL [5374.52-7574.01], = 0.029). OxLDL levels were positively associated with the number of IEs (r = 15.2, B = 0.142 [0.046-0.239], = 0.005) and DBVs (r = 19.2, B = 0.196 [0.018-0.374], = 0.020). This study identified a positive association between elevated serum oxLDL levels and the presence of ≥2 IEs and ≥2 DBVs in CAD patients.
冠状动脉疾病（CAD）的严重程度取决于多种因素。氧化应激会导致脂蛋白氧化，从而引发缺血事件（IEs）和血管损伤（DBVs）。本研究旨在比较根据IEs和DBVs数量分层的CAD患者的生化变量和氧化脂蛋白水平。进行了一项横断面研究，纳入51例确诊为CAD的患者。采用酶联免疫吸附测定法（ELISA）检测血清氧化脂蛋白。与有1次IE和1次DBV的CAD患者相比，有≥2次IE和≥2次DBV的CAD患者显示出更高的氧化型低密度脂蛋白（oxLDL）水平（8293.35纳克/毫升[7131.32 - 9287.39] vs. 6474.26纳克/毫升[5374.52 - 7574.01]，P = 0.029）。oxLDL水平与IEs数量呈正相关（r = 15.2，B = 0.142[0.046 - 0.239]，P = 0.005），与DBVs数量也呈正相关（r = 19.2，B = 0.196[0.018 - 0.374]，P = 0.020）。本研究发现CAD患者血清oxLDL水平升高与存在≥2次IE和≥2次DBV之间存在正相关。
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