高密度脂蛋白代谢与内皮功能。
High-density lipoprotein metabolism and endothelial function.
机构信息
Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
出版信息
Curr Opin Endocrinol Diabetes Obes. 2010 Apr;17(2):166-70. doi: 10.1097/MED.0b013e32833727ee.
PURPOSE OF REVIEW
High-density lipoprotein (HDL) protects against atherosclerosis, transporting cholesterol from peripheral cells to the liver, where it is excreted into the bile. However, HDL also has prominent vascular protective effects.
RECENT FINDINGS
Recent studies have uncovered mechanisms through which HDL decreases vascular inflammation, boosts nitric oxide production, and inhibits thrombosis. The discovery that dysfunctional HDL can also have proinflammatory effects has uncovered a new aspect of HDL biology.
SUMMARY
Low-density lipoprotein is the primary target for drug therapy of dyslipidemias. Drugs that increase HDL also affect additional metabolic pathways. Development of selective drugs targeting key aspects of HDL metabolism may enable us to alter the composition of HDL and inhibit atherogenesis.
目的综述
高密度脂蛋白（HDL）可保护机体免受动脉粥样硬化的影响，其可将胆固醇从外周细胞转运至肝脏，然后被排泄至胆汁中。然而，HDL 还具有突出的血管保护作用。
最近的发现
最近的研究揭示了 HDL 降低血管炎症、促进一氧化氮产生和抑制血栓形成的机制。功能失调的 HDL 也具有促炎作用，这揭示了 HDL 生物学的一个新方面。
总结
低密度脂蛋白是血脂异常药物治疗的主要靶点。增加 HDL 的药物也会影响其他代谢途径。开发针对 HDL 代谢关键方面的选择性药物可能使我们能够改变 HDL 的组成并抑制动脉粥样硬化形成。
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