Esser Karyn A, Su Wen, Matveev Sergey, Wong Vicki, Zeng Li, McCarthy John J, Smart Eric J, Guo Zhenheng, Gong Ming C
Department of Physiology and Graduate Center for Nutritional Sciences, University of Kentucky, 509 Wethington Building, 900 South Limestone, Lexington, KY 40536, USA.
Appl Physiol Nutr Metab. 2007 Aug;32(4):711-20. doi: 10.1139/H07-058.
Physical activity reduces cardiovascular disease related mortality in diabetic patients. However, it is unknown if the diabetic state reduces voluntary physical activity and, if so, if the voluntary physical activity at the reduced level is sufficient to improve cardiovascular risk factors. To address these two specific questions, we investigated voluntary wheel running performance in an obese and type 2 diabetic mouse model, the db/db mice. In addition, we determined the effects of running on body mass, blood glucose, insulin, plasma free fatty acids, cholesterol, and vascular smooth muscle hyper-contractility. Our results showed that daily running distance, time, and speed were significantly reduced in the db/db mice to about 23%, 32%, and 71%, respectively, of that in non-diabetic control mice. However, this low level of running was sufficient to induce a reduction in the vascular smooth muscle hyper-contractility, cholesterol, and some plasma free fatty acids, as well as to delay the decrease in blood insulin. These changes occurred in the absence of weight loss and a detectable decrease in blood glucose. Thus, the results of this study demonstrated that voluntary wheel running activity was dramatically reduced in db/db mice. However, the low levels of running were beneficial, in the absence of effects on obesity or blood glucose, with significant reductions in cardiovascular risk factors and potential delays in beta-cell dysfunction.
体育活动可降低糖尿病患者心血管疾病相关死亡率。然而，糖尿病状态是否会降低自主体育活动尚不清楚；如果会降低，那么降低水平的自主体育活动是否足以改善心血管危险因素也不清楚。为解决这两个具体问题，我们在肥胖且患2型糖尿病的小鼠模型db/db小鼠中研究了自主轮转跑步表现。此外，我们还确定了跑步对体重、血糖、胰岛素、血浆游离脂肪酸、胆固醇以及血管平滑肌过度收缩的影响。我们的结果显示，db/db小鼠的每日跑步距离、时间和速度分别显著降低至非糖尿病对照小鼠的约23%、32%和71%。然而，这种低水平的跑步足以使血管平滑肌过度收缩、胆固醇和一些血浆游离脂肪酸减少，并延缓血液胰岛素水平的下降。这些变化在体重未减轻且血糖未出现可检测到的下降的情况下发生。因此，本研究结果表明db/db小鼠的自主轮转跑步活动显著减少。然而，低水平的跑步是有益的，在不影响肥胖或血糖的情况下，可显著降低心血管危险因素并可能延缓β细胞功能障碍。
