Murakami Kazutaka, Ohashi Atsushi, Hori Hideo, Hibiya Makoto, Shoji Yumiko, Kunisaki Miyuki, Akita Miho, Yagi Akira, Sugiyama Kazuhiro, Shimozato Sachiko, Ito Kazuhiro, Takahashi Hiroki, Takahashi Kazuo, Yamamoto Kouichirou, Kasugai Masami, Kawamura Nahoko, Nakai Shigeru, Hasegawa Midori, Tomita Makoto, Nabeshima Kunihiro, Hiki Yoshiyuki, Sugiyama Satoshi
Department of Nephrology, Fujita Health University School of Medicine, Toyoake, Japan.
Blood Purif. 2007;25(3):290-4. doi: 10.1159/000104869. Epub 2007 Jul 2.
Bisphenol A [BPA, 2,2-bis(4-hydoxyphenyl)propane], an industrial chemical used in the production of polycarbonate, epoxide resin, and polyarylate, is considered to be an endocrine-disrupting chemical. BPA may be present in some hollow-fiber dialyzers used in hemodialysis. In this study, we tested the amounts of BPA eluted from various hollow fibers. Furthermore, we measured the BPA concentration in the sera of 22 renal disease predialysis patients, as well as 15 patients who were receiving hemodialysis, to see if there is BPA accumulation in these patients. The elution test of BPA showed that a much larger amount of BPA was eluted from polysulfone (PS), and polyester-polymeralloy hollow fibers. Among renal disease patients who had not undergone hemodialysis, the serum BPA concentration increased as the renal function deteriorated, showing a significant negative association. In a crossover test between PS and cellulose (Ce) dialyzers, the predialysis serum BPA concentration of PS dialyzer users decreased after changing to a Ce dialyzer, and the serum BPA increased again after switching back to PS dialyzers. In patients who were using PS dialyzers, the BPA level significantly increased after a dialysis session. However, in the Ce dialyzer users, the BPA level decreased. Since accumulation of BPA could affect the endocrine or metabolic system of the human body, it is important to perform further investigations on dialysis patients.
双酚A [BPA，2,2-双（4-羟基苯基）丙烷] 是一种用于生产聚碳酸酯、环氧树脂和聚芳酯的工业化学品，被认为是一种内分泌干扰化学物质。BPA可能存在于血液透析中使用的一些中空纤维透析器中。在本研究中，我们测试了从各种中空纤维中洗脱的BPA量。此外，我们测量了22例肾病透析前患者以及15例正在接受血液透析患者血清中的BPA浓度，以观察这些患者体内是否存在BPA蓄积。BPA的洗脱试验表明，从聚砜（PS）和聚酯-聚合物合金中空纤维中洗脱的BPA量要大得多。在未进行血液透析的肾病患者中，血清BPA浓度随着肾功能恶化而升高，呈现出显著的负相关。在PS透析器和纤维素（Ce）透析器的交叉试验中，使用PS透析器的患者在更换为Ce透析器后透析前血清BPA浓度降低，换回PS透析器后血清BPA浓度再次升高。在使用PS透析器的患者中，透析一次后BPA水平显著升高。然而，在使用Ce透析器的患者中，BPA水平降低。由于BPA的蓄积可能会影响人体的内分泌或代谢系统，因此对透析患者进行进一步研究很重要。
