Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, 13200 Kepala Batas, Penang, Malaysia.
Biomed Res Int. 2022 Aug 16;2022:8227314. doi: 10.1155/2022/8227314. eCollection 2022.
BPA is a known endocrine-disrupting agent that is capable of binding to the estrogen receptor and has exhibited adverse effects in many laboratory animal and in vitro studies. Moreover, it also been shown to have estrogenic, antiandrogenic, inflammatory, and oxidative properties. The widespread presence of BPA in the environment presents a considerable threat to humans. BPA has been shown to be leached into the human ecosystem, where it is commonly found in food products consumed by humans. Although the concentration is relatively low, its prolonged consumption may cause a variety of deleterious health effects. The liver is an important organ for metabolizing and detoxifying toxic metabolites to protect organisms from potentially toxic chemical insults. BPA that is ingested will be eliminated by the liver. However, it has also induced hepatoxicity and injury via various mechanisms. To find research demonstrating the effects of BPA on kidney, a number of databases, including Google Scholar, MEDLINE, PubMed, and the Directory of Open Access Journals, were searched. Thus, this review summarizes the research on the relationship between BPA and its effects on the liver-derived from animals and cellular studies. The underlying mechanism of liver injury caused by BPA is also elucidated.
BPA 是一种已知的内分泌干扰物，能够与雌激素受体结合，并在许多实验室动物和体外研究中表现出不良反应。此外，它还具有雌激素、抗雄激素、炎症和氧化作用。BPA 在环境中的广泛存在对人类构成了相当大的威胁。BPA 已被证明会浸出到人类生态系统中，在人类食用的食品中普遍存在。尽管浓度相对较低，但长期摄入可能会导致各种有害的健康影响。肝脏是代谢和解毒有毒代谢物的重要器官，可保护机体免受潜在有毒化学物质的侵害。摄入的 BPA 将被肝脏消除。然而，它也通过多种机制诱导了肝毒性和损伤。为了寻找证明 BPA 对肾脏影响的研究，检索了包括 Google Scholar、MEDLINE、PubMed 和开放获取期刊目录在内的多个数据库。因此，本综述总结了 BPA 与动物和细胞研究中肝脏损伤关系的研究。还阐明了 BPA 引起肝损伤的潜在机制。
