Larsson Britta Wåhlin, Kadi Fawzi, Ulfberg Jan, Aulin Karin Piehl
Department of Health and Social Sciences, Dalarna University, Falun, Sweden.
Eur Neurol. 2007;58(3):133-7. doi: 10.1159/000104712. Epub 2007 Jun 29.
The aim of the study was to assess the cellular and structural properties of skeletal muscle in restless legs syndrome (RLS).
Twenty patients and 16 controls were included. Aerobic performance was assessed using a submaximal test. On muscle biopsies taken from the tibialis anterior, fiber distribution and fiber area were analyzed together with parameters surveying the microvascularization, especially the tortuosity, which is expressed as a percent of muscle fiber perimeter in contact with the wall of the microvessel, length of capillary/perimeter of fiber (LC/PF) index.
The RLS group had significantly lower predicted maximal oxygen uptake (p = 0.01) and significantly higher LC/PF index (p = 0.01) compared to the controls.
The higher capillary tortuosity in RLS patients indicates the occurrence of significant remodeling in capillary geometry in RLS.
本研究旨在评估不宁腿综合征（RLS）患者骨骼肌的细胞和结构特性。
纳入20例患者和16例对照。采用次极量试验评估有氧运动能力。对取自胫前肌的肌肉活检标本，分析纤维分布和纤维面积，并测量微血管化参数，特别是曲折度，其以与微血管壁接触的肌纤维周长的百分比表示，即毛细血管长度/纤维周长（LC/PF）指数。
与对照组相比，RLS组的预测最大摄氧量显著降低（p = 0.01），LC/PF指数显著升高（p = 0.01）。
RLS患者较高的毛细血管曲折度表明RLS患者毛细血管几何形状发生了显著重塑。
