Uttner I, Weber S, Freund W, Schmitz B, Ramspott M, Huber R
Department of Neurology, University of Ulm, Ulm, Germany.
Eur Neurol. 2007;58(3):146-51. doi: 10.1159/000104715. Epub 2007 Jun 29.
Transient global amnesia (TGA) is a clinical syndrome of unknown etiology characterized by sudden onset anterograde amnesia, which was thought to resolve completely. However, some authors have also suggested permanent memory impairment. It is unclear whether these results reflect a true persistent damage or a simply too short assessment interval in the context of a prolonged recovery phase after TGA. To evaluate the cognitive long-term outcome, 16 patients who had suffered from TGA at a mean of 3 years before and 15 healthy controls underwent a comprehensive neuropsychological test battery. No significant differences between patients' and controls' cognitive performance were found, irrespectively of the analyzed neuropsychological domain. Therefore we hypothesize that TGA usually does not cause persistent cognitive deficits due to a generally transient and prognostic benign character.
短暂性全面性遗忘症（TGA）是一种病因不明的临床综合征，其特征为突然发作的顺行性遗忘，以往认为会完全恢复。然而，一些作者也提出存在永久性记忆损害。目前尚不清楚这些结果是反映了真正的持续性损害，还是仅仅因为TGA后恢复阶段延长，评估间隔时间过短所致。为了评估认知功能的长期转归，对16例平均在3年前患过TGA的患者和15名健康对照者进行了全面的神经心理测试组。无论分析的是哪个神经心理领域，患者与对照者的认知表现均未发现显著差异。因此，我们推测，由于TGA通常具有短暂性和预后良好的特点，一般不会导致持续性认知缺陷。
