Tharakan Binu, Dhanasekaran Muralikrishnan, Mize-Berge Janna, Manyam Bala V
Department of Neurology, Scott & White Clinic, Temple, Texas, USA.
Phytother Res. 2007 Dec;21(12):1124-6. doi: 10.1002/ptr.2219.
Levodopa is considered the 'gold standard' for the treatment of Parkinson's disease. However, a serious concern is dyskinesia and motor fluctuation that occurs after several years of use. In vitro experiments have shown that in the presence of divalent copper ions, levodopa may induce intense DNA damage. Mucuna pruriens cotyledon powder (MPCP) has shown anti-parkinson and neuroprotective effects in animal models of Parkinson's disease that is superior to synthetic levodopa. In the present study two different doses of MPCP protected both plasmid DNA and genomic DNA against levodopa and divalent copper-induced DNA strand scission and damage. It exhibited chelation of divalent copper ions in a dose-dependent manner. The copper chelating property may be one of the mechanisms by which MPCP exerts its protective effects on DNA.
左旋多巴被认为是治疗帕金森病的“金标准”。然而，一个严重的问题是使用几年后会出现运动障碍和运动波动。体外实验表明，在二价铜离子存在的情况下，左旋多巴可能会导致严重的DNA损伤。刺蒺藜子叶粉（MPCP）在帕金森病动物模型中显示出优于合成左旋多巴的抗帕金森和神经保护作用。在本研究中，两种不同剂量的MPCP保护质粒DNA和基因组DNA免受左旋多巴和二价铜诱导的DNA链断裂和损伤。它以剂量依赖的方式表现出对二价铜离子的螯合作用。铜螯合特性可能是MPCP对DNA发挥保护作用的机制之一。
