Marrosu F, Maleci A, Cocco E, Puligheddu M, Barberini L, Marrosu M G
Dipartimento di Scienze Neurologiche e Cardiovascolari, University of Cagliari, Italy.
Mult Scler. 2007 Nov;13(9):1200-2. doi: 10.1177/1352458507078399. Epub 2007 Jul 10.
Vagus nerve stimulation (VNS), an adjunctive approach for the treatment of epilepsy, was performed in three multiple sclerosis (MS) patients displaying postural cerebellar tremor (PCT) and dysphagia. Following VNS, improvement of PCT and dysphagia was manifested over a period of two and three months, respectively. In view of the involvement of the main brainstem visceral component of the vagus, the nucleus tractus solitarius (NTS), in modulating central pattern generators (CPGs) linked to both olive complex pathway and swallowing, improvement is likely to be VNS related. The results obtained suggest an additional therapeutic application for VNS and may represent a novel form of treatment in patients with severe MS.
迷走神经刺激术（VNS）是一种治疗癫痫的辅助方法，对三名患有姿势性小脑震颤（PCT）和吞咽困难的多发性硬化症（MS）患者实施了该手术。VNS术后，PCT和吞咽困难分别在两个月和三个月的时间内得到改善。鉴于迷走神经主要的脑干内脏成分孤束核（NTS）参与调节与橄榄复合体通路和吞咽相关的中枢模式发生器（CPG），这种改善可能与VNS有关。所获得的结果表明VNS有额外的治疗应用价值，并且可能代表了一种针对重症MS患者的新型治疗方式。
