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1
Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.钙信号传导、离子通道等等。DT40系统作为脊椎动物离子稳态和细胞生理学的模型。
Subcell Biochem. 2006;40:257-70.
2
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3
Human Trp3 forms both inositol trisphosphate receptor-dependent and receptor-independent store-operated cation channels in DT40 avian B lymphocytes.人源Trp3在DT40禽B淋巴细胞中形成肌醇三磷酸受体依赖性和非受体依赖性的储存式阳离子通道。
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4
Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.利用鸡B淋巴细胞系DT40进行同源DNA重组的反向遗传学研究。
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Methods to evaluate Zinc transport into and out of the secretory and endosomal-lysosomal compartments in DT40 cells.评估锌进出DT40细胞分泌和内体-溶酶体区室的方法。
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本文引用的文献

1
The role of canonical transient receptor potential 7 in B-cell receptor-activated channels.典型瞬时受体电位7在B细胞受体激活通道中的作用。
J Biol Chem. 2005 Oct 21;280(42):35346-51. doi: 10.1074/jbc.M507606200. Epub 2005 Aug 25.
2
Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.位于分泌途径中的阳离子扩散促进蛋白的两种不同锌转运复合物在脊椎动物细胞中发挥作用以激活碱性磷酸酶。
J Biol Chem. 2005 Sep 2;280(35):30956-62. doi: 10.1074/jbc.M506902200. Epub 2005 Jul 1.
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Rapid functional assays of recombinant IP3 receptors.重组肌醇三磷酸受体的快速功能测定
Cell Calcium. 2005 Jul;38(1):45-51. doi: 10.1016/j.ceca.2005.04.001.
4
Expression of a truncated form of inositol 1,4,5-trisphosphate receptor type III in the cytosol of DT40 triple inositol 1,4,5-trisphosphate receptor-knockout cells.截短形式的肌醇1,4,5-三磷酸受体III在DT40肌醇1,4,5-三磷酸受体三重敲除细胞胞质溶胶中的表达。
Cell Calcium. 2005 Feb;37(2):97-104. doi: 10.1016/j.ceca.2004.03.005.
5
Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.锌转运蛋白ZnT5和ZnT7是激活碱性磷酸酶所必需的，碱性磷酸酶是一种需要锌的酶，通过糖基磷脂酰肌醇锚定在细胞质膜上。
J Biol Chem. 2005 Jan 7;280(1):637-43. doi: 10.1074/jbc.M411247200. Epub 2004 Nov 2.
6
Modification of intracellular Ca2+ dynamics by laser inactivation of inositol 1,4,5-trisphosphate receptor using membrane-permeant probes.使用膜渗透性探针通过激光灭活肌醇1,4,5-三磷酸受体来改变细胞内钙离子动力学。
Chem Biol. 2004 Aug;11(8):1053-8. doi: 10.1016/j.chembiol.2004.05.012.
7
Functional analysis of the green fluorescent protein-tagged inositol 1,4,5-trisphosphate receptor type 3 in Ca(2+) release and entry in DT40 B lymphocytes.绿色荧光蛋白标记的1,4,5-三磷酸肌醇3型受体在DT40 B淋巴细胞钙释放和内流中的功能分析
Biochem J. 2004 Sep 15;382(Pt 3):793-801. doi: 10.1042/BJ20031970.
8
Thimerosal stimulates Ca2+ flux through inositol 1,4,5-trisphosphate receptor type 1, but not type 3, via modulation of an isoform-specific Ca2+-dependent intramolecular interaction.硫柳汞通过调节一种亚型特异性的钙离子依赖性分子内相互作用，刺激钙离子通过1型肌醇1,4,5-三磷酸受体流动，但不刺激3型。
Biochem J. 2004 Jul 1;381(Pt 1):87-96. doi: 10.1042/BJ20040072.
9
Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.双功能离子通道/蛋白激酶：脊椎动物镁调节机制的新组分
Pediatr Res. 2004 May;55(5):734-7. doi: 10.1203/01.PDR.0000117848.37520.A2. Epub 2004 Feb 5.
10
Regulation of the type 1 inositol 1,4,5-trisphosphate receptor by phosphorylation at tyrosine 353.酪氨酸353位点磷酸化对1型肌醇1,4,5-三磷酸受体的调控
J Biol Chem. 2004 Apr 16;279(16):16311-6. doi: 10.1074/jbc.M400206200. Epub 2004 Feb 3.

钙信号传导、离子通道等等。DT40系统作为脊椎动物离子稳态和细胞生理学的模型。

Calcium signaling, ion channels and more. The DT40 system as a model of vertebrate ion homeostasis and cell physiology.

作者信息

Perraud Anne-Laure, Schmitz Carsten, Scharenberg Andrew M

机构信息

Dept. of Immunology, University of Colorado and National Jewish Medical Research Hospital, Denver, CO, USA.

出版信息

Subcell Biochem. 2006;40:257-70.

PMID:17623910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3628819/
Abstract

The DT40 B-lymphocyte cell line is a chicken bursal lymphocyte tumor cell line which grows rapidly, expresses a variety of types of constitutive and signal dependent ion transport systems., and supports the efficient use of stable and conditional genetic manipulations. Below, we review the use of DT40 cells in dissecting molecular mechanisms involved in Ca2+, Mg2+, and Zn2+ transport physiology. These studies highlight the flexibility and advantages the DT40 environment offers to investigators interested in the study of basic vertebrate ion transport physiology.

摘要

DT40 B淋巴细胞系是一种鸡法氏囊淋巴细胞肿瘤细胞系，其生长迅速，表达多种组成型和信号依赖性离子转运系统，并支持稳定和条件性基因操作的有效应用。下文将综述DT40细胞在剖析Ca2+、Mg2+和Zn2+转输生理学所涉及的分子机制中的应用。这些研究突出了DT40环境为有志于研究基础脊椎动物离子转输生理学的研究者所提供的灵活性和优势。