Schmitz Carsten, Perraud Anne-Laure, Fleig Andrea, Scharenberg Andrew M
Department of Pediatrics, University of Washington and Children's Hospital and Regional Medical Center, Seattle, WA 98195, USA.
Pediatr Res. 2004 May;55(5):734-7. doi: 10.1203/01.PDR.0000117848.37520.A2. Epub 2004 Feb 5.
Although magnesium is the dominant divalent intracellular cation and is required for the function of diverse types of enzymes that participate in virtually every cellular process, the molecular mechanisms that regulate its homeostasis are poorly understood. Electrophysiologic and biochemical investigations of a novel dual-function ion channel/kinase protein have recently converged with the identification of the gene locus for an autosomal recessive form of inherited hypomagnesemia to provide new insight into vertebrate magnesium regulatory mechanisms.
尽管镁是细胞内主要的二价阳离子，并且参与几乎所有细胞过程的多种酶的功能都需要它，但调节其体内平衡的分子机制却知之甚少。最近，对一种新型双功能离子通道/激酶蛋白的电生理和生化研究，与常染色体隐性遗传性低镁血症的基因位点的鉴定相结合，为脊椎动物镁调节机制提供了新的见解。
