产生甲胎蛋白的卵巢透明细胞腺癌：病例报告
Ovarian clear cell adenocarcinoma producing alpha-fetoprotein: case report.
作者信息
Cetin A, Bahat Z, Cilesiz P, Demirbağ N, Yavuz E
机构信息
Department of Obstetrics and Gynecology, Haseki Education and Research Hospital, Istanbul, Turkey.
出版信息
Eur J Gynaecol Oncol. 2007;28(3):241-4.
BACKGROUND
Alpha-fetoprotein (AFP) is a useful tumor marker for germ cell tumors of the ovary and is valuable for both diagnosis and follow-up. However, it is very rare for an epithelial ovarian carcinoma to secrete AFP.
CASE
We report a case of a 63-year-old woman with a ovarian clear cell carcinoma with serous component of less than 10%. Both histological components were producing AFP as demonstrated by immunohistochemistry. After surgery and chemotherapy, AFP decreased to normal range. The patient also had elevated CA-125 levels but the tumor was negative for CA-125 which suggested the increased CA-125 might have been due to the associated ascites.
CONCLUSION
Ovarian clear cell type carcinomas rarely secrete only AFP and it might be the single marker that could be used in follow-up.
背景
甲胎蛋白（AFP）是卵巢生殖细胞肿瘤的一种有用的肿瘤标志物，对诊断和随访均有价值。然而，上皮性卵巢癌分泌AFP的情况非常罕见。
病例
我们报告一例63岁女性，患有卵巢透明细胞癌，浆液性成分少于10%。免疫组化显示两种组织学成分均产生AFP。手术和化疗后，AFP降至正常范围。患者CA-125水平也升高，但肿瘤CA-125呈阴性，这表明CA-125升高可能是由于合并腹水所致。
结论
卵巢透明细胞型癌很少仅分泌AFP，它可能是可用于随访的单一标志物。
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