Guo Shuhong, Yan Jingqi, Yang Tangbin, Yang Xianqiang, Bezard Erwan, Zhao Baolu
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Academia Sinica, Beijing, China.
Biol Psychiatry. 2007 Dec 15;62(12):1353-62. doi: 10.1016/j.biopsych.2007.04.020. Epub 2007 Jul 12.
Nitric oxide (NO) and related pathways are thought to play an important role in the pathogenesis of Parkinson's disease (PD). Our in vitro experiments suggested that green tea polyphenols (GTP) might protect dopamine neurons through inhibition of NO and reactive oxygen species (ROS).
Immunohistochemistry, terminal deoxynucleotidyl transferase-mediated dUTP Nick End Labeling assay, electron spin resonance spin trapping, enzyme linked immunosorbent assay, and molecular biological methods were used to investigate the effects of GTP in an unilateral 6-hydroxydopamine (6-OHDA)-treated rat model of PD.
GTP treatment dose-dependently protected dopaminergic neurons by preventing from midbrain and striatal 6-OHDA-induced increase in 1) both ROS and NO levels, 2) lipid peroxidation, 3) nitrite/nitrate content, 4) inducible nitric oxide synthase, and 5) protein-bound 3-nitro-tyrosine. Moreover, GTP treatment dose-dependently preserved the free radical scavenging capability of both the midbrain and the striatum.
These results support the in vivo protection of GTP against 6-OHDA and suggest that GTP treatment might represent a neuroprotective treatment of PD.
一氧化氮(NO)及相关信号通路被认为在帕金森病(PD)的发病机制中起重要作用。我们的体外实验表明,绿茶多酚(GTP)可能通过抑制NO和活性氧(ROS)来保护多巴胺能神经元。
采用免疫组织化学、末端脱氧核苷酸转移酶介导的dUTP缺口末端标记法、电子自旋共振自旋捕集法、酶联免疫吸附测定法和分子生物学方法,研究GTP对单侧6-羟基多巴胺(6-OHDA)处理的PD大鼠模型的影响。
GTP处理通过防止中脑和纹状体6-OHDA诱导的以下各项增加,呈剂量依赖性地保护多巴胺能神经元:1)ROS和NO水平;2)脂质过氧化;3)亚硝酸盐/硝酸盐含量;4)诱导型一氧化氮合酶;5)蛋白质结合的3-硝基酪氨酸。此外,GTP处理呈剂量依赖性地保留了中脑和纹状体的自由基清除能力。
这些结果支持GTP对6-OHDA的体内保护作用,并表明GTP治疗可能是一种PD的神经保护治疗方法。