Bezman Natalie, Koretzky Gary A
Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
Immunol Rev. 2007 Aug;218:9-28. doi: 10.1111/j.1600-065X.2007.00541.x.
Adapters are multidomain molecules that recruit effector proteins during signal transduction by immunoreceptors and integrins. The absence of these scaffolding molecules profoundly affects development and function of various hematopoietic lineages, underscoring their importance as regulators of signaling cascades. An emerging aspect of the mechanism by which engaged immunoreceptors and integrins transmit signals within the cell is by differential usage of various adapters that function to nucleate formation of distinct signaling complexes in a specific location within the cell. In this review, we discuss the mechanisms by which adapter proteins coordinate signal transduction with an emphasis on the role of subcellular compartmentalization in adapter function.
衔接蛋白是多结构域分子，在免疫受体和整合素介导的信号转导过程中招募效应蛋白。这些支架分子的缺失会深刻影响各种造血谱系的发育和功能，突显了它们作为信号级联调节因子的重要性。免疫受体和整合素在细胞内传递信号的机制中一个新出现的方面是，通过不同地使用各种衔接蛋白，这些衔接蛋白在细胞内特定位置形成不同信号复合物的过程中发挥成核作用。在本综述中，我们讨论衔接蛋白协调信号转导的机制，重点关注亚细胞区室化在衔接蛋白功能中的作用。
